RT期刊文章SR电子T1眼部症状后免疫抑制剂检查站。乔(p3.4 - 013)摩首页根富林明神经病学神经病学FD Lippincott Williams &威尔金斯SP p3.4补充92 - 013签证官是15 A1奈尔Fotedar A1 Hemani Ticku A1 Vishakhadatta Mathur Kumaraswamy A1丹尼尔·米勒A1马克·科恩A1迈克尔·摩根A1 Komal Sawlani年2019 UL //www.ez-admanager.com/content/92/15_supplement/p3.4 - 013. -文摘AB目的:报告一例一系列4病人并回顾相关的文献对神经肌肉的几种不良事件(ira)的免疫抑制剂检查站(ICPis),特别是眼部弱点参与和开发一个接近这些病人的诊断算法。背景:ICPis癌症治疗使用的不断增加导致了爱尔兰共和军的广泛的认可,包括神经肌肉疾病。而神经肌肉接点(NMJ)障碍与眼部症状,通常被认为是肌炎、眼外肌肉转移,脱髓鞘疾病也应该差。测试为管理这些方案势在必行。设计/方法:回顾四眼患者的弱点,发达之后收到ICPisResults:所有四个患者接受ICPis和发达眼部症状。四分之三的患者也有呼吸困难、吞咽困难或近端无力。患者1的检查显示高乙酰胆碱受体抗体(乙酰胆碱受体)和CK水平升高。上直肌肌肉的尸检,活检显示肌炎。因此,神经肌肉软弱是次要irMyositis和可能的NMJ障碍。病人2的检查显示-乙酰胆碱受体抗体测试,CK水平升高,肌电图肌病运动单位,和三头肌肌肉活检显示肌炎; thus, neuromuscular weakness was secondary to irMyositis. Patient 3’s work-up showed mildly elevated CK level, positive AChR antibodies, and EMG evidence of a demyelinating neuropathy. Deltoid muscle biopsy showed myositis; thus neuromuscular weakness was secondary to irMyositis, irDemyelinating neuropathy and possible irNMJ disorder. Patient 4 presented with diplopia only with normal CK level and negative AChR antibody testing. MRI Orbit revealed evidence of a metastasis to the left superior oblique muscle.Conclusions: Ocular symptoms following ICPi therapy does not always represent a neuromuscular junction disorder. It is important to include myositis, demyelinating neuropathies, and orbital metastases to the differential because the natural history and management are variable.Disclosure: Dr. Fotedar has nothing to disclose. Dr. Ticku has nothing to disclose. Dr. Mathur Kumaraswamy has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Cohen has nothing to disclose. Dr. Morgan has nothing to disclose. Dr. Sawlani has nothing to disclose.

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