首页TY - JOUR T1 - Prosodic Impairment as a Marker of apoE4 Status in logopenic variant Primary Progressive Aphasia with AD Pathology (P2.1-032) JF - Neurology JO - Neurology VL - 92 IS - 15 Supplement SP - P2.1-032 AU - Naomi Nevler AU - Sharon Ash AU - David Irwin AU - Mark Liberman AU - Murray Grossman Y1 - 2019/04/09 UR - //www.ez-admanager.com/content/92/15_Supplement/P2.1-032.abstract N2 - Objective: To explore the effects of underlying Alzheimer's disease (AD) pathology on impaired prosody in patients with logopenic variant Primary Progressive Aphasia (lvPPA).Background: We previously reported on a limited range of fundamental frequency (f0, the physical property of sound typically used to represent perceived pitch) in a group of non-aphasic patients with behavioral variant Frontotemporal Degeneration (FTD).最近,我们在非流水语法PA中展示了相似发现,并联系到脑旋流语义变异PPA病人显示无缺陷预科范围,对数开源变异PPA病人显示中间缺陷ivpoteine4e4e4e在这个组中,我们比较F0范围aE4平均值为68+10y4+2y平均值为MMSE24sultss:ivPA中携带aE4(4.63+0.9ST)的病人比非载体(5.42+1.22ST)大为限制f0范围P=0.03,MMSE评分和疾病持续时间为大共变数)最适态回归模型引申f0范围(coef=-20.8),男性性(coeff=-76.7)和年龄(ceff=6.7)高预测CSF中的Abta42级(R2=0.37,p=0.04)。内夫勒没有什么可透露博士Ash没什么可透露博士欧文没什么可透露博士Liberman因咨询、科学咨询委员会服务、演讲或与美国百度研究LexCheck的其他活动而获得个人补偿博士Liberman以编辑身份获得年度评审个人补偿博士Grossman因咨询、科学咨询委服务或与GE Whitney的其他活动而获得个人补偿博士首页Grossman以神经学编辑身份获得个人补偿博士Grossman从Biogen获得研究支持ER-