TY - T1的韵律损伤的标志在logopenic apoE4地位变体原发性进行性失语与AD病理(p2.1 - 032) JF -神经学乔-神经学六世- 92 - 15补充SP - p2.1 - 032 AU - Naomi Nevler盟沙龙灰非盟-大卫欧文盟马克Liberman AU -首页莫里格罗斯曼Y1 - 2019/04/09 UR - //www.ez-admanager.com/content/92/15_supplement/p2.1 - 032. -抽象N2 -目的:探索潜在的影响阿尔茨海默病(AD)病理学在患者受损的韵律logopenic变体原发性进行性失语(lvPPA)。背景:我们之前报道在有限范围的基本频率(f0,声音的物理性质通常用来代表认为沥青)在一群non-aphasic行为变异患者额颞叶退化(FTD)。最近我们在nonfluent-agrammatic PPA演示了一个类似的发现,与脑脊液(CSF)和相关的磷酸化水平τ(pTau)。语义变体PPA患者没有障碍的韵律,而logopenic变体PPA患者(lvPPA)表现出一个中间障碍。我们假设恶化的韵律范围lvPPA携带载脂蛋白E e4 apoE4基因型。设计/方法:我们自动分割和数字化分析半结构化的语音样本来自29个lvPPA患者轻度降低f0范围(平均5.0±1.87半音来)。这组我们比较f0范围内apoE4的运营商(n = 9, 44%的男性,平均年龄68±10 y,意味着疾病持续时间4±2 y,意味着MMSE 24)与非携带者(n = 15, 26%男性,平均年龄65±7 y,平均病程3.5±1.5 y,意味着MMSE 20),这些人口特征的共变。在6个月内患者CSF的子集的音频集合(n = 22)我们跑线性回归模型关联f0范围、性别与年龄的预测Abeta42水平。结果:有f0范围的一个重要限制lvPPA患者apoE4的载体(平均4.63±0.9)相比,非承运人(5.42±1.82;p = 0.03, MMSE评分和疾病持续时间显著covariables)。最适合的回归模型与f0范围(系数。=−20.8),男性(系数。=−76.7)和年龄(多项式系数= 6.7)的高度预测Abeta42水平CSF (R2 = 0.37, p = 0.04)。Conclusions: Impaired f0 range is a potential clinical marker for underlying AD pathology associated with apoE4 in patients with an lvPPA phenotype.Disclosure: Dr. Nevler has nothing to disclose. Dr. Ash has nothing to disclose. Dr. Irwin has nothing to disclose. Dr. Liberman has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Baidu Research USA and LexCheck. Dr. Liberman has received personal compensation in an editorial capacity for Annual Reviews. Dr. Grossman has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with GE Whitney. Dr. Grossman has received personal compensation in an editorial capacity for Neurology. Dr. Grossman has received research support from Biogen. ER -