PT -期刊文章盟安妮Lannuzel AU - jean - louis Ferge盟昆汀Lobjois盟Aissatou Signate AU -罗兹Benoit盟Benoit Tressieres AU -雅安Madec AU -帕斯卡尔Poullain AU -塞西尔·赫尔曼盟Fatiha Najioullah AU - Eavan麦戈文盟Anne-Charlotte Savigan Sebastien Breurec AU -红润华伦天奴盟盟雷蒙德Cesaire AU -艾蒂安Hirsch盟Pierre-Marie Lledo盟Guillaume Thiery AU -安德烈Cabie盟弗朗索瓦丝Lazarini AU - Emmanuel罗兹Neurozika TI -长期的结果:当生物诊断问题(S45.008) DP - 2019年4月09年TA -神经病学PG - S45.008 VI - 92 IP - 15补充4099 - //www.ez-admanager.com/content/92/15_Supplement/S45.008.short 4100 - //www.ez-admanager.com/content/92/15_Supplement/S45.008.full所以Neurology201首页9 4月09年;92 AB -目的:描述完整的光谱,神经系统表现的相对频率和预后Zika病毒(ZIKV)产后感染。背景:Zika病毒(ZIKV)产后感染与中央有关和外围神经系统表现。完整的光谱,这些神经系统表现的相对频率和预后尚未被描述。设计/方法:我们进行了一项观察性研究在连续ZIKV-infected患者出现神经系统表现在2016年法属西印度群岛的爆发。结果:八十八名患者,包括六个孩子,被录取。百分之九十五的情况下,需要住院治疗。格林-巴利综合征是最常见的表现(46.6%),其次是脑炎、脑脊髓炎(20.5%)、孤立的单个或多个颅神经麻痹(9.1%),其它外围表现(6.8%),和中风(1.1%)。14例(15.9%),包括一个孩子,开发了一种混合涉及中枢和周围神经系统的紊乱。需要机械通气在21例的ZIKV RNA在至少一个生物流体。由于neuroZika两个成年患者死亡。临床随访(平均14个月; interquartile range, 12–17) was available for 77 patients. Residual disability (modified Rankin scale ≥2) was identified in 19 (24.7%) patients, in 6 cases (7.8%), disability was severe (modified Rankin scale ≥4). Amongst patients with ZIKV RNA detected in one biological fluid, the risk of residual disability or death was higher (odd ratio, 9.97; CI, 1.22 to 81.21; P=0.032).Conclusions: NeuroZika spectrum represents a heterogenous group of clinical neurological manifestations. During an outbreak, clinicians should consider neuroZika in patients presenting with cranial nerve palsies and a mixed neurological disorder. Long-term sequelae are frequent in NeuroZika. ZIKV reverse-transcription PCR status at admission can inform prognosis and should therefore be taken into consideration in the management of hospitalised patients.Disclosure: Dr. Lannuzel has nothing to disclose. Dr. Ferge has nothing to disclose. Dr. Lobjois has nothing to disclose. Dr. Signate has nothing to disclose. Dr. Roze has nothing to disclose. Dr. Tressières has nothing to disclose. Dr. Madec has nothing to disclose. Dr. Poullain has nothing to disclose. Dr. Herrmann has nothing to disclose. Dr. Najioullah has nothing to disclose. Dr. McGovern has nothing to disclose. Dr. Savigan has nothing to disclose. Dr. Valentino has nothing to disclose. Dr. Breurec has nothing to disclose. Dr. Cesaire has nothing to disclose. Dr. Hirsch has nothing to disclose. Dr. Lledo has nothing to disclose. Dr. Thiery has nothing to disclose. Dr. Cabie has nothing to disclose. Dr. Lazarini has nothing to disclose. Dr. Roze has nothing to disclose.