TY - T1的中央静脉签署和顺Rim在白质病变的影像上孤立综合症(S6.003) JF -神经学乔-神经学六世- 92 - 15补充Jiwon哦SP - S6.003盟盟——Suradech Suthiphosuwan盟——媚兰Guenette盟玛蒂娜Absinta AU首页 -丹尼尔帝国盟Aditya Bharatha AU - Pascal Sati Y1 - 2019/04/09 UR - //www.ez-admanager.com/content/92/15_Supplement/S6.003.abstract N2 -目的:评估存在的中央静脉标志(CVS)和顺Rim标志(PRS)白质病变(WML)的放射检查孤立综合症(RIS)。背景:RIS描述无症状患者的放射异常提示多发性硬化症(MS)。最近susceptibility-based磁共振成像研究表明,很大比例的wml MS患者可见中央静脉(CVS),可以帮助区分从其他女士白质紊乱。此外,子群的慢性病变可以证明女士增加磁化率沿病变边缘(顺rim签署(PRS)),这可能是慢性、活跃的炎症。设计/方法:15个人RIS接受3.0 t MRI获得3 d-flair和EPI 3 d-t2 *。CVS和PRS评估在wml T2 *大小和相位图像。结果:所有的RIS例在这项研究wml积极招募CVS (CVS +)。CVS的平均比例+ wml每箱是83%。14(93%)中央静脉在WML的40%,会议提出阈值来区分从其他女士的疾病之一。PRS在场的11例(73%),和wml的平均比例积极PRS (PRS +)每箱是19%。PRS缺席4 RIS例(27%):3总损伤较低加载(9-25 WML),和1 CVS + WML的比例最低(31%)。有着很强的相关性之间的比例CVS + WML和PRS + WML(术中ρ= 0.86,0.001)。Conclusions: In our sample, most RIS cases had a large proportion of CVS+WMLs, indicating perivenular pathology. Furthermore, a large (though smaller) proportion also had PRS+WMLs. RIS cases without PRS had low WML load and/or low proportions of CVS+WML. These findings suggest that the majority of RIS subjects harbor subclinical chronic active demyelination and may be at risk of eventually developing progressive clinical symptoms. Both CVS and PRS could potentially be useful to differentiate true RIS from mimickers. Prospective follow-up of this cohort is planned, which will enable a better understanding of the differential diagnostic and predictive value of the CVS and PRS in RIS.Disclosure: Dr. Oh has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with EMD-Serono, Novartis, Biogen-Idec, Sanofi-Genzyme, Roche, Celgene. Dr. Oh has received research support from Biogen-Idec, Sanofi-Genzyme. Dr. Suthiphosuwan has received research support from Sanofi-Genzyme.. Dr. Guenette has nothing to disclose. Dr. Absinta has nothing to disclose. Dr. Reich has nothing to disclose. Dr. Bharatha has nothing to disclose. Dr. Sati has nothing to disclose. ER -