TY - T1的缺血性中风后的早期预测恶性脑水肿:系统回顾和荟萃分析(p3.9 - 010) JF -神经学乔-神经学六世- 92 - 15补充SP - p3.9 - 010 AU -去吴盟Ruozhen元盟-延安王盟陈忱魏盟Shihong吴张盟-杨小燕盟盟-明刘Y1首页 - 2019/04/09 UR - //www.ez-admanager.com/content/92/15_supplement/p3.9 - 010. -抽象N2 -目的:识别发展的可靠标记缺血性中风后恶性脑水肿。背景:恶性脑水肿后缺血性中风死亡率高,很难治疗。早期预测是很重要的通知有针对性的预防和更密集的监控。然而,目前还没有可靠的预测恶性脑水肿。设计/方法:我们搜查了Medline和Embase从开始到2018年3月,包括研究评估预测或预测模型对缺血性中风后恶性脑水肿。学习素质是由一个测量表评估工具。优势比,平均差异,或标准均数差值合成在随机建模。预测模型进行了描述性的分析。结果:我们包括38个研究(3278名患者)和24的临床因素,7域成像标记,13个血清生物标志物,和4模型。一般来说,包括研究小和显示潜在的发表偏倚。恶性脑水肿与年轻有关(n = 2075; mean difference, −4.42, 95% confidence interval [CI], −6.63 to −2.22), higher admission National Institute of Health Stroke Scale scores (n=807, median 17–20 versus 5.5–15), and parenchymal hypoattenuation >50% of the middle cerebral artery territory on initial computed tomography (n=420; odds ratio, 5.33; 95% CI, 2.93–9.68). Revascularization (n=1600, odds ratio, 0.37; 95% CI, 0.24–0.57) were associated with a lower risk for malignant edema. Four predictive models all showed an overall C statistic >0.70, with a risk of overfitting.Conclusions: Younger age, higher National Institute of Health Stroke Scale, and larger parenchymal hypoattenuation on computed tomography are reliable early predictors for malignant edema. Revascularization reduces the risk of malignant edema. No firm conclusion could be drawn for other factors due to the limited data and diversity in study characteristics. Future studies with robust design are needed to explore optimal cutoff age and National Institute of Health Stroke Scale scores and to validate and improve existing models.Disclosure: Dr. Wu has nothing to disclose. Dr. Yuan has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Wei has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Yang has nothing to disclose. Dr. Wu has nothing to disclose. Dr. Ming has nothing to disclose. ER -