PT -期刊文章盟宝拉代理盟Luiza Piovesana AU - Mateus Nogueira盟瑞秋吉马良斯盟-奥古斯托·阿马托球场盟费尔南多Cendes盟Iscia Lopes-Cendes TI - AU -克拉丽莎Yasuda白质显微结构的变化在亨廷顿疾病:当神经退行性变的开始吗?(p1.8 - 050) DP - 2019年4月09年TA -神首页经病学第六PG - p1.8 - 050 - 92 IP - 15补充4099 - //www.ez-admanager.com/content/92/15_supplement/p1.8 050. - 050.短4100 - //www.ez-admanager.com/content/92/15_supplement/p1.8 - -全所以Neurology2019 4月09年;92 AB -目的:描述白质(WM)改变亨廷顿病(HD)患者使用扩散张量成像(DTI)分析。背景:虽然高清症状主要解释了在尾状变性,核,杏仁核,有相当大的变化在发病的年龄,症状严重程度和患者的神经退化。因此,有一个额外的努力更好地描述结构的MRI改变高清。HD患者的影像学研究可能有助于确定神经退化过程的微分中枢神经系统结构的脆弱性以及更精确地确定神经退化启动时,它是如何发展和可能的关联的触发器。设计/方法:我们获得的DTI 37控制和36例,年龄性别平衡。病人接受神经系统评估:统一高清量表- UHDRS项目。DTI与ExploreDTI / matlab - 2014处理。十大港[3部分胼胝体(CC)皮质脊髓束(CST) Infero-frontooccipital (IFO) Infero-longitudinal纤维束董继玲女士背和海马旁瓣环(PH-CINGULUM),钩状的和穹窿的身体(穹窿)]被划定tractography屈服分数各向异性(FA)(图)。SPSS22用于相关性,单变量、多变量分析和卡方检验。Results: ANOVA analyses for bilateral tracts revealed significant dorsal and PH-cingulum FA reduction (p<0.004) in HD patients. MANOVA of CC segments and FORNIX showed reduced FA (p<0.0125). While there was no significant correlation between FA and CAG expansion, we identified significant correlation between UHDRS and CST (p<0.005), IFO (p<0.002) and left PH-CINGULUM (p=0.003). There was a positive correlation between MOCA and PH-CINGULUM FA (p<0.002).Conclusions: WM alterations were widespread, affecting midline and bilateral structures. Possible mechanisms underlying these findings: 1)Preferential connections loss along radial direction (striatopallidal connections); 2)Pathological processes combination (neuronal loss, astrocytosis, cell permeability); 3)Increased metalloprotein-bound-iron deposit.The abnormal tracts are responsible for sensorimotor integration, motor control and planning, visuospatial function and emotional processing. Prospective studies are underway to characterize how the pattern of WM alterations progresses in HD.Disclosure: Dr. Azevedo has nothing to disclose. Dr. Piovesana has nothing to disclose. Dr. Nogueira has nothing to disclose. Dr. Guimarães has nothing to disclose. Dr. Amato-Filho has nothing to disclose. Dr. Cendes has nothing to disclose. Dr. Lopes-Cendes has nothing to disclose. Dr. Yasuda has nothing to disclose.