% Ezequiel Gleichgerrcht 0期刊文章% %一个达芬奇Bonilha % Deqiang秋%克里斯托弗Leatherday %一个奈杰尔·皮德森娜塔莉·沃特% %乔恩·T·威利大卫·劳瑞% %丹尼尔Drane Robert总值% % T映射说明性文字记忆的神经基础:证据来自中央的颞叶病变(p3.1 - 014) % D J神经病学2019% % P p3.1 - 014 V % 92% N % X 15补充目的:识别的神经基质支持声明性语言记忆的不同阶段。首页背景:当前的陈述性记忆的神经解剖学的模型规定海马及其邻近结构之间的共同作用来支持编码、存储和恢复人类大脑的信息。我们的理解这些过程是功能性神经成像研究的结果(如fMRI),哪个寄存器时大脑活动参与者完成给定的任务。这些技术允许我们识别的神经生物学基础的一些认知神经激活,但他们只提供间接措施从而无法可靠地分辨哪些大脑区域真正重要的对于一个给定的函数。解决这个问题可以在lesion-symptom映射(LSM),一种方法的行为性能统计相关受损的脑组织,因此检测大脑结构是至关重要的对于一个给定的行为。迄今为止,LSM对记忆功能的研究是有限的可能由于缺乏离散的内侧颞叶病变常见脑缺血性中风等侮辱。立体定向激光amygdalohippocampotomy (SLAH)越来越多的手术技术治疗医学的耐火材料内侧颞叶癫痫(MRMTLE)产生在大脑病变在这样的地区。设计/方法:我们进行了分布LSM 13例(40岁±18.4;30%的男性)和MRMTLE left-predominant语言(如证实了功能磁共振成像或和田或两者)接受左SLAH。我们分析了收购,立即召回,延迟回忆标准化的Z分数Rey听觉言语学习任务在6个月对象。结果:LSM透露,收购与海马损伤相关的批判性而直接和延迟回忆阶段的任务都与嗅皮质损伤有关。结论:我们的结果显示分离海马和海马旁陈述性记忆的完整性进行整合与检索方面,分别。披露:Gleichgerrcht博士没有披露。Bonilha博士已经收到个人赔偿咨询、担任科学顾问委员会说,与飞利浦或其他活动。 Dr. Bonilha has received research support from Medtronic. Dr. Qiu has nothing to disclose. Dr. Leatherday has nothing to disclose. Dr. Voets has nothing to disclose. Dr. Pedersen has nothing to disclose. Dr. Loring has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with NeuroPace. Dr. Loring has received personal compensation in an editorial capacity for Epilepsia and Neuropsychology Review. Dr. Loring has received research support from Medtronic. Dr. Willie has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Medtronic, Inc. and Neuropace, Inc. Dr. Willie has received research support from Medtronic, Inc., Neuropace, Inc., and Nico, Inc. Dr. Gross has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Medtronic, Boston Scientific, Neuropace, Biomet Zimmer, and Abbott. Dr. Gross has received research support from Medtronic, Boston Scientific, Neuropace, and Voyager. Dr. Drane has nothing to disclose. %U