Ezequiel Gleichgerrcht PT -期刊文章盟盟-莱昂纳多Bonilha盟Deqiang邱AU -克里斯托弗Leatherday盟娜塔莉·沃特盟奈杰尔·皮德森AU -大卫·劳瑞盟乔恩·t·威利AU -罗伯特总盟丹尼尔Drane TI -映射说明性文字记忆的神经基础:证据来自中央的颞叶病变(p3.1 - 014) DP - 2019年4月09年TA -神经病学第六PG - p3.1 - 014 - 92 IP - 15补充4099 - //www.ez-admanager.com/content/92/15_supplement/p3.1 014. - 014.短4100 - //www.ez-admanager.com/content/92/15_supplement/p3.1 - -全所以Neuro首页logy2019 4月09年;92 AB -目的:识别的神经基质支持声明性语言记忆的不同阶段。背景:当前的陈述性记忆的神经解剖学的模型规定海马及其邻近结构之间的共同作用来支持编码、存储和恢复人类大脑的信息。我们的理解这些过程是功能性神经成像研究的结果(如fMRI),哪个寄存器时大脑活动参与者完成给定的任务。这些技术允许我们识别的神经生物学基础的一些认知神经激活,但他们只提供间接措施从而无法可靠地分辨哪些大脑区域真正重要的对于一个给定的函数。解决这个问题可以在lesion-symptom映射(LSM),一种方法的行为性能统计相关受损的脑组织,因此检测大脑结构是至关重要的对于一个给定的行为。迄今为止,LSM对记忆功能的研究是有限的可能由于缺乏离散的内侧颞叶病变常见脑缺血性中风等侮辱。立体定向激光amygdalohippocampotomy (SLAH)越来越多的手术技术治疗医学的耐火材料内侧颞叶癫痫(MRMTLE)产生在大脑病变在这样的地区。设计/方法:我们进行了分布LSM 13例(40岁±18.4;30%的男性)和MRMTLE left-predominant语言(如证实了功能磁共振成像或和田或两者)接受左SLAH。我们分析了收购,立即召回,延迟回忆标准化的Z分数Rey听觉言语学习任务在6个月对象。Results: LSM revealed that acquisition was critically associated with hippocampal damage while both immediate and delayed recall phases of the task were associated with entorhinal damage.Conclusions: Our results suggest a dissociation of hippocampal vs. parahippocampal integrity for consolidation vs. retrieval aspects of declarative memory, respectively.Disclosure: Dr. Gleichgerrcht has nothing to disclose. Dr. Bonilha has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Philips. Dr. Bonilha has received research support from Medtronic. Dr. Qiu has nothing to disclose. Dr. Leatherday has nothing to disclose. Dr. Voets has nothing to disclose. Dr. Pedersen has nothing to disclose. Dr. Loring has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with NeuroPace. Dr. Loring has received personal compensation in an editorial capacity for Epilepsia and Neuropsychology Review. Dr. Loring has received research support from Medtronic. Dr. Willie has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Medtronic, Inc. and Neuropace, Inc. Dr. Willie has received research support from Medtronic, Inc., Neuropace, Inc., and Nico, Inc. Dr. Gross has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Medtronic, Boston Scientific, Neuropace, Biomet Zimmer, and Abbott. Dr. Gross has received research support from Medtronic, Boston Scientific, Neuropace, and Voyager. Dr. Drane has nothing to disclose.