% 0期刊文章%尤金Scharf %斯科特Przybelski乔纳森Graff-Radford % % Gregory Preboske David Knopman % %克里斯托弗·施瓦兹%一个马太Senjem %杰弗瑞甘特% Kejal Kantarci %罗纳德·彼得森米歇尔Mielke % % Clifford杰克% Prashanthi Vemuri % T心血管和代谢危险因素发展的脑小血管疾病:纵向天赋成像在梅奥诊所研究衰老(p5.3 - 057) % D J神经病学2019% % P p5.3 - 057 V % 92% N % X 15补充目的:确定心血管和代谢危险因素的影响(负责人)发展的白质高密度人口基数。首页背景:脑小血管疾病(CSVD)是一种血管性认知障碍的主要原因和混合社区老年痴呆;它可以评估的白质hyperintensities FLAIR-MRI(负责人)。越来越多的证据表明一个代谢疾病健康和负责人的发展之间的联系。然而,特定的心血管和代谢危险因素的影响发展的负责人是不完全理解。设计/方法:回顾性队列包括参与者参加的梅奥诊所研究衰老,奥姆斯特德县纵向以人群为基础的研究,明尼苏达州至少连续2负责人评估FLAIR-MRIs (n = 434 > = 65年中年的评估)与基线测量体重指数、静息血压、糖化血红蛋白、空腹血糖、脂质面板。混合模型被用来确定基线的特定组件与改变相关代谢疾病风险负责人规范化颅内总额。这些分析是控制了年龄和性别。结果:年龄和女性性别与更大的研究负责人有关(p < 0.001)。基线高血压(p < 0.001),中年高血压(p = 0.003),和基线糖化血红蛋白(p = 0.027)的预测增加负责人跟进。高密度脂蛋白(HDL)、低密度脂蛋白(LDL),甘油三酯,身体质量指数(BMI)没有与负责人增加有关。 In sensitivity analyses, associations between hypertension and increased WMH progression were stronger in women.Conclusions: Hypertension (both mid and late life) and hemoglobin A1c were the strongest modifiable predictors associated with serial increases in WMH in this cohort. The association of hypertension and increased WMH was more pronounced in women. Further investigations should explore how changes in metabolic risk factors influence this aspect of CVSD.Disclosure: Dr. Scharf has nothing to disclose. Dr. Graff-Radford has nothing to disclose. Dr. Przybelski has nothing to disclose. Dr. Knopman has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Washington University for the DIAN study. Dr. Knopman has received research support from Biogen Pharmaceuticals and Lilly Pharmaceuticals. Dr. Preboske has nothing to disclose. Dr. Schwarz has nothing to disclose. Dr. Senjem has nothing to disclose. Dr. Gunter has nothing to disclose. Dr. Kantarci has nothing to disclose. Dr. Mielke has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Eli Lilly and Lysosomal Therapeutics, Inc. Dr. Mielke has received research support from Biogen, Roche, and Lundbeck. Dr. Petersen has nothing to disclose. Dr. Jack has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Eli Lily. Dr. Vemuri has nothing to disclose. %U