RT期刊文章SR电子T1横断面和纵向CPE的累积分数不与神经认知障碍在瑞士成功老龄化HIV阳性(S29.008)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP S29.008 VO 92 15补充A1 Galia桑托斯A1伊莎贝拉A1右路放倒媚兰Metral A1亚历山德拉Calmy A1 Thanh Lecompte A1 Christoph豪泽A1亚莉克希亚Cusini A1芭芭拉·哈斯首页A1海伦Kovari A1菲利普·塔尔A1 Marcel Stoeckle A1 Christoph Fux A1卡罗琳di Benedetto A1帕特里克•施密德A1凯瑟琳亲爱的A1马提亚Cavassini A1 Renaud Du Pasquier年2019 UL //www.ez-admanager.com/content/92/15_Supplement/S29.008.abstract AB目的:分析潜在中枢神经系统渗透效果之间的联系(CPE)许多抗逆转录病毒药物和神经认知障碍(NCI)在艾滋病毒携带者。背景:神经认知障碍(NCI)在艾滋病毒携带者(PLWH)仍然是一个问题,尽管联合抗逆转录病毒疗法(cART)。中枢神经系统渗透效率更高(CPE)分数与更好的中枢神经系统有关艾滋病毒复制控制,但CPE和癌症之间的联系仍然是有争议的。设计/方法:神经认知评估代谢和老化队列(NAMACO)研究中,瑞士艾滋病病毒的亚群体队列研究(自燃),招收了909名艾滋病毒阳性aviraemic自燃≥45岁的参与者。所有的参与者进行了标准化的神经认知评估。横断面CPE分数(在神经认知评估)和累积CPE分数(总结CPE分数从车启动的时候神经认知评估)检查作为潜在预测NCI的多元逻辑回归模型。结果:大多数患者是男性(80%)和白人(92%)。都无法觉察的血浆hiv rna在神经认知评估。NCI在40%,其中有26.4%的艾滋病毒相关癌症:25%无症状神经认知障碍,0.8%有轻微的神经认知障碍与艾滋病痴呆和0.6%。所有的CPE分数,无论是横向还是累积,与NCI统计上显著相关。结论:在这个大成功艾滋病毒阳性人群,四分之一的人口被诊断出患有艾滋病毒相关癌症。我们观察到没有NCI和横截面之间的联系或小说累积CPE的分数。披露:桑托斯博士没有披露。 Dr. Locatelli has nothing to disclose. Dr. Metral has nothing to disclose. Dr. Calmy has nothing to disclose. Dr. Lecompte has nothing to disclose. Dr. Hauser has nothing to disclose. Dr. Cusini has nothing to disclose. Dr. hasse has nothing to disclose. Dr. Kovari has nothing to disclose. Dr. Tarr has nothing to disclose. Dr. Stoeckle has nothing to disclose. Dr. Fux has nothing to disclose. Dr. di Benedetto has nothing to disclose. Dr. Schmid has nothing to disclose. Dr. Darling has nothing to disclose. Dr. Cavassini has nothing to disclose. Dr. Du Pasquier has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Biogen, Roche, and Sanofi.