PT -期刊文章AU -威廉姆斯Shawniqua罗伯森盟Naureen Azeez AU - Randip希夫AU -布伦达t .双关AU -詹姆斯·c·杰克逊盟Pratik p Pandharipande AU - e·韦斯利·伊利TI脑电图特征之间的关系在关键认知障碍疾病和长期(4832)DP - 2020年4月14日TA -神经病学PG - 4832 VI - 94 IP - 15补充4099 - //www.ez-admanager.com/content/94/15_Supplement/4832.short 4100 - //www.ez-admanager.com/content/94/15_Supplement/首页4832.full所以Neurology2020 4月14日;94 AB -目的:比较脑电图(EEG)特征在关键疾病患者的1年期神经心理的结果。背景:多达30% -80%的ICU幸存者遭受禁用长期认知障碍(LTCI),包括内存和执行功能障碍,在重要的疾病。ICU谵妄LTCI的危险因素,潜在的病理生理学是知之甚少。脑电图无创评估神经生理活动和显示特征发现谵妄。然而,缺乏数据检查脑电图特征之间的关系在疾病和LTCI至关重要。设计/方法:我们进行了因果分析的患者在BRAIN-ICU研究(Pandharipande NEJM 2013)经历了脑电图临床用途在指数(N = 10)的承认。我们包括所有参与者与住院病人脑电图记录完成认知评估(可重复的电池神经心理评估的状态——我国)在12个月的随访。我们评估常规脑电图特征通过目视检查和计算11定量脑电图特征(四光谱波段光谱带的力量和可变性,两半球间的连贯性和近似熵)使用MATLAB®。LTCI的脑电图特征和模式之间的关系进行了探讨用斯皮尔曼等级相关。Results: Of the 10 patients (50% female, median age 45 years), 7 screened positive for delirium or coma within 24 hours of EEG. All but one EEG showed generalized background slowing. Relative alpha power correlated with visuospatial/constructional ability (VC; rho=0.78, p=0.008). Peak interhemispheric coherence correlated negatively with delayed memory (DM; rho=−0.81, p=0.018). This relationship appeared stronger among EEGs recorded in ICU (rho=−1.0, p=0.017). Among ICU EEGs, theta-range spectral variability also correlated negatively with DM (rho=−0.89, p=0.033).All patients demonstrated cognitive impairment in at least one domain at follow-up. The most common deficits occurred in DM (median index 62) and VC (median index 69).Conclusions: These data support subsequent investigation of the hypothesis that there is a relationship between EEG characteristics during critical illness and long-term cognitive impairment.Disclosure: Dr. Williams Roberson has received research support from Masimo Corporation. Dr. Azeez has nothing to disclose. Dr. Taneja has nothing to disclose. Dr. Pun has nothing to disclose. Dr. Jackson has nothing to disclose. Dr. Pandharipande has received research support from Masimo Corporation; Eisai Inc.. Dr. Ely has received research support from Masimo Corporation.

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