PT -期刊文章盟Bhavesh Trikamji盟利亚Brancheck AU -格雷戈里天盟鲍勃Bucelli TI -免疫介导radiculoneuropathy与血清anti-Lgi-1相关自身抗体(2327)DP - 2021年4月13日TA -神经病学PG - 2327 VI - 96 IP - 15补充4099 - //www.ez-admanager.com/content/96/15_Supplement/首页2327.short 4100 - //www.ez-admanager.com/content/96/15_Supplement/2327.full所以Neurology2021 4月13;96 AB -目的:描述两种情况突出小说协会瞬态anti-leucine-rich神经胶质瘤inactivated-1 (Lgi-1)血清阳性免疫介导radiculoneuropathy acute-to-subacute发病。背景:Anti-Lgi-1自身抗体与广泛的中部和周围神经系统疾病,包括小纤维和自主神经病变,自身免疫性痴呆和边缘脑炎面部与臂的矛盾的行之有效的前驱症状的发作。而抗体电压门控钾通道(VGKC)复杂可能缺乏特异性神经疾病,该领域的专家考虑自身抗体中的特定Lgi-1蛋白质VGKC复杂,高度特定神经自身免疫。设计/方法:例1是62岁的老人与快速进步提升弱点指出有发烧、假性脑膜炎、淋巴结病扩散和斑丘疹的皮疹。他收到了广谱抗生素治疗可能的脑膜炎。实验室检查是显著的嗜酸性粒细胞,脑脊液蛋白升高与嗜中性白血球增多。成像显示弥漫性淋巴结病。他的四肢瘫痪的进展,随后用丙种球蛋白治疗。电诊法的显示严重,亚急性感觉电机轴突的神经病变。返回Lgi-1抗体阳性血清自身抗体测试。 Following a course of intensive rehabilitation he had improvement of strength and spontaneous resolution of rash, leukocytosis, eosinophilia, and lymphadenopathy. Repeat serum testing for anti-Lgi-1 antibodies returned negative. At no point, the patient developed any features of autoimmune encephalopathy/encephalitis.Results: Case 2 is 73-year-old man with subacute gait instability and ascending pattern of sensory loss. CSF analysis showed albumin-cytological gradient. Electrodiagnostics showed mixed axonal and demyelinating polyneuropathy. Serum autoantibody testing showed elevated striational and Lgi-1 autoantibodies. He received plasma exchange with improvement of symptoms. He gradually developed worsening weakness with profound motor and sensory deficits and generalized areflexia. Repeat CSF was comparable to prior. MRI showed diffuse enhancement of nerve roots throughout. Repeat serum testing for Lgi-1 antibodies returned negative. He received corticosteroid and rituximab with resolution of weakness.Conclusions: Neurologists need to be aware of this unique association.Disclosure: Dr. Trikamji has nothing to disclose. Dr. Brancheck has nothing to disclose. Dr. Day has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Parabon Nanolabs. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for DynaMed (EBSCO Health). Dr. Day has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Barrow Law. The institution of Dr. Day has received research support from National Institutes of Health. The institution of Dr. Day has received research support from Chan Zuckerberg Initiative. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Presenter at regional meeting (CME) with Texas Neurological Society. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Grant Review (honorarium) with Pennsylvania Department of Health . Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Presenter at Annual Meeting (CME) with American Academy of Neurology. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Authorship with Continuum. Dr. Day has a non-compensated relationship as a Clinical Director with AntiNMDA Receptor Encephalitis Foundation that is relevant to AAN interests or activities. Dr. Bucelli has received stock or an ownership interest from Neuroquestions.com. An immediate family member of Dr. Bucelli has received stock or an ownership interest from Neuroquestions.com. Dr. Bucelli has received publishing royalties from a publication relating to health care.