% 0期刊文章%一个泽Darweesh %弗兰克Wolters % m . Kamran Ikram %一个彼得Koudstaal布鲁诺斯特里克% % m .伊Arfan % T严重认知功能与事件的风险增加有关帕金森症:鹿特丹研究(S22.007) % D J神经病学2017% % P S22.007 X % V % 88% N 16补充目的:研究认知功能与事件帕金森症协会以社区为基础的群体。首页背景:认知障碍是帕金森症患者中一个共同的特点,但有一个稀缺的数据在这些患者的认知功能帕金森症的诊断。设计/方法:从2002年到2008年,我们在8324年评估认知功能研究参与者的鹿特丹是帕金森症和老年痴呆症的自由。我们使用四个测试(斯特鲁,Letter-Digit-Subtraction-Test LDST,语言流畅,词汇学习测试[电缆测试])和派生一个全球认知得分从主成分分析。随后,我们跟着参与者对帕金森症的发作,直到2015年1月。我们确定协会的认知功能与事件震颤麻痹,调整了年龄、性别、学习subcohort,和教育。在单独的敏感性分析,我们排除了:1)第一个五年的随访;2)人与微妙的汽车特性(任何帕金森签名或者可怜的手灵巧度);3)继发性帕金森症,只留下帕金森病,与路易体痴呆和未指明的帕金森症;和4)人事件前震颤麻痹痴呆。结果:随访期间(平均8.2年),92事件参与者被诊断出患有帕金森症,其中53例(58%)与帕金森病。事件的帕金森症患者,31日事件也被诊断患有痴呆震颤麻痹发病后之前和18 (13)。 Lower global cognition was associated with a higher risk of incident parkinsonism (hazard ratio per −1 standard deviation [HR]=1.94, 95% confidence interval [1.51;2.50]). The association remained robust beyond the first five years (HR=1.66[1.16;2.38]) and after exclusion of persons with subtle motor features (HR=1.75[1.19;2.58]), secondary parkinsonism (1.63[1.23;2.17]), or incident dementia (HR=1.89[1.41;2.53]). LDST (HR=1.68[1.30;2.18]), Verbal Fluency (HR=1.63[1.27;2.08]), and inverted Stroop (HR=1.64[1.33;2.02]) scores were each strongly associated with incident parkinsonism, whereas the association of WLT scores was distinctly weaker (HR= 1.23[1.57;0.97]).Conclusions: Worse cognitive functioning is associated with an increased risk of incident parkinsonism. Importantly, the association is not driven by diagnostic delay, and extends beyond patients with secondary parkinsonism.Study Supported by: Stichting Parkinson FondsDisclosure: Dr. Darweesh has nothing to disclose. Dr. Wolters has nothing to disclose. Dr. Ikram has nothing to disclose. Dr. Stricker has nothing to disclose. Dr. Koudstaal has nothing to disclose. Dr. Ikram has nothing to disclose. %U

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