@article {Song1293作者= {Suhang歌曲和Yunglin凝视Seonjoo李和基督教Habeck班斯特恩和燕顾},title ={身体活动负担和温和派之间的相关性白质高密度认知变化(p5 - 5.001)},体积={98},数量={18补充},elocation-id ={1293} ={2022},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:检查是否身体活动(PA)(负责人)温和派之间的相关性白质高密度负担和认知变化。首页背景:高负责人负担已被证明预测更快的认知衰退在年底的时候。然而,一些受试者保持相对稳定的认知尽管高负责人负担由于更好的认知储备。是否参与考评的可以提供认知储备(CR)减轻负责人和认知变化之间的关系尚不清楚。设计/方法:这个队列研究是在198年进行dementia-free {\ textendash} 80岁的成年人。休闲体育活动(LTPA)被一个LTPA自我报告的问卷评估光,温和,和剧烈的运动。职业体育活动(OPA)是一个因素得分测量物理的要求每个工作,源自246年的主成分分析工作特性根据职业信息网络。结果变量包括五年变化在全球认知和四个能力(流体推理、处理速度、内存和词汇)估计潜在的变化分数有六个认知任务/能力。总PA是LTPA, OPA的z得分的总和。并运用多元线性回归方法估计PA的适度效应包括交互项(PA *负责人)。所有模型都是调整年龄、性别、教育和基线认知。结果:五年来,全球认知(平均差[follow-up-baseline] (SE) = -0.010 (0.018), p \ < 0.001)、推理(diff (SE) = -0.152 (0.010), p \ < 0.001)、速度(diff (SE) = -0.181 (0.013), p \ < 0.001),和内存(diff (SE) = -0.125 (0.049), p = 0.006)的分数下降,和词汇(diff (SE) = 0.059 (0.013), p \ < 0.001)有所改善。 Higher WMH was correlated with greater decline in global cognition (Spearman{\textquoteright}s rho=-0.215, p=0.002), reasoning (rho=-0.380, p\<0.001) and speed (rho=-0.314, p\<0.001), and less increase in vocabulary (rho=-0.300, p\<0.001). Greater total PA and OPA attenuated the association between WMH and changes in reasoning (βTPA*WMH[SE]=0.011[0.005], p=0.040; βOPA*WMH[SE]=0.013[0.006], p=0.043) and speed (βTPA*WMH[SE]=0.013[0.007], p=0.075; βOPA*WMH[SE]=0.016[0.009], p=0.065).Conclusions: PA may provide CR to maintain reasoning and speed in face of WMH. Understanding mechanisms underlying this potential reserve is warranted in further studies.Disclosure: Dr. Song has nothing to disclose. Dr. Gazes has nothing to disclose. Dr. Lee has received personal compensation for serving as an employee of New York State Psychiatric Institute. Christian Habeck has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Alzheimer{\textquoteright}s Prevention and Therapy Foundation. The institution of Christian Habeck has received research support from National Insitutes of Health. Dr. Stern has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Stern has received intellectual property interests from a discovery or technology relating to health care. Dr. Stern has received publishing royalties from a publication relating to health care. The institution of Dr. Gu has received research support from NIH.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/98/18_Supplement/1293}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }