TY - T1的后代性别和父母在成年中年和老年认知(p1 - 3.004) JF -神经学乔-神经学六世- 98 - 18补充SP - 970 AU -凯特琳Wolfova AU - Di吴盟-乔丹维首页斯盟Pavla Cermakova AU -汉斯科勒盟Vegard Fykse Skirbekk AU -班斯特恩AU -艾莉森Gemmill盟-萨拉汤姆Y1 - 2022/05/03 UR - //www.ez-admanager.com/content/98/18_Supplement/970.abstract N2 -目标:我们的目标是检查后代之间的关系性和父母的基线水平的认知和老年人认知能力的下降。背景:研究表明后代性之间的联系和孕产妇长期健康状况,包括老年痴呆症。提出的一个解释是胎儿起源的男性微嵌合体。我们假设至少1男孩的母亲会比母亲更好的认知,没有男孩,和父亲就没有差异。设计/方法:我们分析了一群来自美国的13777名成年人≥50岁健康和退休的研究。后代性别分为没有男孩和至少1男孩在主要分析和数量的男孩(0,1孩子,2个男孩,3或更多男孩)和数量的女孩(2 1 0女孩,女孩,女孩,3或更多的女孩)的二次分析。认知评估使用成绩之和从直接和延迟10-noun自由回忆测试,连续7 s减法测试和向后计数测试。关联使用线性mixed-effects模型进行评估,调整为1)基线年龄,性别,种族,平价;2)社会经济因素;和3)健康相关因素和婚姻状况。结果:总共有17.7%的受访者没有男孩,60.1%的受访者是女性。分层在父母的性别、母亲和父亲的至少1男孩明显高于基线认知相比,那些没有男孩。 Associations were attenuated in adjusted models. In secondary analysis, having 3 or more boys was associated with higher baseline cognition in fathers, there were no differences in mothers. We found a significant association of cognitive decline with number of boys, but not with number of girls.Conclusions: Offspring sex was associated with cognitive aging among both mothers and fathers, suggesting interplay of biological and social influences.Disclosure: Dr. Wolfova has nothing to disclose. Mr. Wu has nothing to disclose. Mr. Kohler has nothing to disclose. Prof. Skirbekk has nothing to disclose. Dr. Stern has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Stern has received intellectual property interests from a discovery or technology relating to health care. Dr. Stern has received publishing royalties from a publication relating to health care. Prof. Gemmill has received research support from National Institutes of Health and the Robert Wood Johnson Foundation. Prof. Gemmill has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant with World Health Organization. The institution of Sarah Tom has received research support from National Institutes of Health . Sarah Tom has received personal compensation in the range of $500-$4,999 for serving as a Consultant with Alzheimer's Association . ER -