电子T1敏感性和特异性RT老杂志文章的三个筛选问题认知障碍(P2.303)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP P2.303 VO 88是16补充A1梅勒妮Metral A1伊莎贝拉A1右路放倒海伦Kovar首页i A1亚历山德拉Calmy A1 Klemens Gutbrod A1彼得brgger A1 Andreas Monsch A1凯瑟琳亲爱的A1 Renaud Du Pasquier A1马提亚Cavassini年2017 UL //www.ez-admanager.com/content/88/16_Supplement/P2.303.abstract AB目的:本研究旨在确定筛选问题的敏感性和特异性检测艾滋病毒相关神经认知障碍(手)。背景:为了提高检测的手,欧洲艾滋病临床社会(eac)建议问三个eac筛选问题(收)有关记忆丧失、精神放缓,和注意力障碍。设计/方法:在这个未来的正在进行的多中心队列研究嵌入到瑞士艾滋病队列研究,899例45岁以上的人登记,问先生之前进行一次彻底的标准化的神经心理学评估包括情绪量表(鉴定)。敏感性,特异性,阳性(PPV)和负(NPV)预测值先生的神经认知障碍(非传染性疾病)计算。结果:我们的队列(平均年龄55±7.5年,80%的男性,92%的白人)有高比例的检测不到病毒载量(96%,六世< 50拷贝/毫升;当前的CD4细胞632 / mm3和中值值最低点CD4细胞180 / mm3)。收,25%回答“是的绝对”至少一次。在这组,非传染性疾病的患病率是51%:25%,主要是由于手和26%的混杂因素。其中674名患者筛选-先生,非传染性疾病的患病率是37%:27.5%,主要是由于手和9.5%的“其他”。收的敏感性和特异性分别为31.6%和79.4%。相应的PPV和NPV分别为0.51和0.62,分别为0.34和0.69时,分析局限于手。当无症状神经认知障碍(ANI)被排除在非传染性疾病的定义和视为正常,PPV和NPV分别为0.30和0.90。 The association between positive answers both at ESQ and CES-D was statistically significant (p <0.001).Conclusions: The ESQ exhibited a poor PPV and NPV for the diagnosis of HAND. When ANI was excluded, the ESQ had a good NPV to rule out symptomatic NCD. Higher depression scores were significantly associated with positive answers to the ESQ.Disclosure: Dr. Métral has nothing to disclose. Dr. Locatelli has nothing to disclose. Dr. Kovari has nothing to disclose. Dr. Calmy has nothing to disclose. Dr. Gutbrod has nothing to disclose. Dr. Brugger has nothing to disclose. Dr. Monsch has received personal compensation for activities with Novartis and Schwabe. Dr. Monsch has received research support from Zinfandel Pharmaceuticals. Dr. Darling has nothing to disclose. Dr. Du Pasquier has received personal compensation for activities with Biogen, Novartis, Abbott, ViiV, EMD Serono, and Merck Sharp & Dohme Ltd. Dr. Cavassini has received research support from Merck Sharp & Dohme Ltd., and Gilead.