PT -期刊文章盟劳拉Mora-Munoz AU -诺亚安德鲁斯盟Matheus Araujo盟Loutfi Aboussouan AU -威廉·宾格曼盟鲁王盟-玛德琳Grigg-Damberger盟南希Foldvary Schaefer TI -后发作的广义脑电图抑制,不睡眠状态,与Peri-Ictal呼吸干扰Stereoelectroencephalography记录Perisylvian癫痫(S6.007)援助- 10.1212 / WNL。0000000000202987 DP - 2023年4月25日TA -神经病首页学第六PG - 3054 - 100 IP - 17补充2 4099 - //www.ez-admanager.com/content/100/17_Supplement_2/3054.short 4100 - //www.ez-admanager.com/content/100/17_Supplement_2/3054.full所以Neurology2023 4月25日;100 AB -目的:识别peri-ictal呼吸干扰与postictal广义脑电图抑制(网页)和睡眠。背景:Seizure-related呼吸功能障碍可能会使癫痫突然意外死亡(癫痫),然而,现有的研究主要基于头皮录音和缺乏全面的障碍(PSG)信号。网页(缺乏脑电图活动在10μv)提出了生物标志物的癫痫和癫痫发生在大多数情况下睡觉。设计/方法:我们研究了呼吸的变化stereoelectroencephalography (SEEG)记录perisylvian发作使用多通道系统集成脑电图和PSG信号包括气流、努力、动脉血氧饱和度和二氧化碳。睡眠状态和网页是由头皮电极(FZ / CZ)。可翻译的录音需要动脉血氧饱和度和至少一个通道气流和努力。呼吸事件得分在焦和推广阶段。事件的频率和持续时间是由州和网页状态相比使用两个示例t检验或克鲁斯卡尔-沃利斯检验基于0.05显著性水平使用SAS 9.4软件。结果:61例癫痫(29例)包括在内。相比癫痫没有网页,网页癫痫(N = 8)与更高的中央有关的事件的发生频率(中位数(差):3.0(3.0,4.0)和1.0(1.0,1.0),术中;0.001)和持续时间(76(63、94)和27 12.5,35秒,P = 0.010); higher ictal RR (mean±SD: 28.5±1.5 vs 24.6±4.6 bpm, P<0.001), pre-ictal-to-ictal RR change (8.1±3.2 vs 2.3±3.2 bpm, P<0.001) and pre-ictal-to-peak TcpCO2 change (16.4 [11.6,31.0] vs 2.2 [0.45,7.2] mmHg, P=0.023); and greater pre-ictal-to-nadir SPO2 change (24.0 [23.0,24.4] vs 4.1 [2.4,11.0] %, P=0.033). However, PGES was not associated with sleep state. In contrast, sleep seizures (N=35) were differentiated from wake seizures only by lower pre-ictal (19.9±2.5 vs 24.1±3.1 bpm, P<0.001), ictal (22.6±4.3 vs 28.0±2.7 bpm, P<0.001), and postictal RR (24.7±5.22 vs 8.5±4.4 bpm, P=0.020), and higher pre-ictal TcpCO2 (40.6[38.1, 42.6] vs 36.8[32.8, 39.5] mmHg, P=0.006).Conclusions: PGES (and not sleep) in perisylvian seizures is associated with a host of respiratory disturbances, providing further support of its role as a biomarker of SUDEP.Disclosure: Dr. Mora Munoz has nothing to disclose. Noah Andrews has nothing to disclose. Dr. Araujo has received personal compensation for serving as an employee of International Business Machines. Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Araujo has received research support from Inspire Medical System. Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving as a Consultant with One Heart Health. Dr. Aboussouan has received publishing royalties from a publication relating to health care. William Bingaman has nothing to disclose. Lu Wang has nothing to disclose. Dr. Grigg-Damberger has received personal compensation for serving as an employee of Oxford University Press. Dr. Grigg-Damberger has received personal compensation for serving as an employee of Up-to-date. Dr. Grigg-Damberger has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of Clinical Sleep Medicine. Dr. Grigg-Damberger has received publishing royalties from a publication relating to health care. Dr. Foldvary-Schaefer has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jazz. The institution of Dr. Foldvary-Schaefer has received research support from Jazz. The institution of Dr. Foldvary-Schaefer has received research support from Suven. The institution of Dr. Foldvary-Schaefer has received research support from Takeda. Dr. Foldvary-Schaefer has received publishing royalties from a publication relating to health care. Dr. Foldvary-Schaefer has received publishing royalties from a publication relating to health care.