RT期刊文章SR电子T1后发作的广义脑电图抑制,不睡眠状态,与Peri-Ictal呼吸干扰Stereoelectroencephalography记录Perisylvian癫痫(S6.007)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 3054 10.1212 / WNL。首页0000000000202987签证官100 17补充2 A1劳拉Mora-Munoz A1诺亚安德鲁斯A1 Matheus Araujo A1 Loutfi Aboussouan A1威廉宾格曼A1 Lu Wang A1玛德琳Grigg-Damberger A1南希Foldvary Schaefer年2023 UL //www.ez-admanager.com/content/100/17_Supplement_2/3054.abstract 首页AB目的:识别peri-ictal呼吸干扰与postictal广义脑电图抑制(网页)和睡眠。背景:Seizure-related呼吸功能障碍可能会使癫痫突然意外死亡(癫痫),然而,现有的研究主要基于头皮录音和缺乏全面的障碍(PSG)信号。网页(缺乏脑电图活动> 10μv)提出了生物标志物的癫痫和癫痫发生在大多数情况下睡觉。设计/方法:我们研究了呼吸的变化stereoelectroencephalography (SEEG)记录perisylvian发作使用多通道系统集成脑电图和PSG信号包括气流、努力、动脉血氧饱和度和二氧化碳。睡眠状态和网页是由头皮电极(FZ / CZ)。可翻译的录音需要动脉血氧饱和度和至少一个通道气流和努力。呼吸事件得分在焦和推广阶段。事件的频率和持续时间是由州和网页状态相比使用两个示例t检验或克鲁斯卡尔-沃利斯检验基于0.05显著性水平使用SAS 9.4软件。结果:61例癫痫(29例)包括在内。相比癫痫没有网页,网页癫痫(N = 8)与中央的事件的发生频率更高(中值(差):3.0(3.0,4.0)和1.0 (1.0,1.0),P < 0.001)和持续时间(76(63、94)和27 12.5,35秒,P = 0.010);更高的猝发的RR(平均数±标准差:bpm 28.5±1.5 vs 24.6±4.6, P < 0.001), pre-ictal-to-ictal RR变化(bpm 8.1±3.2 vs 2.3±3.2, P < 0.001)和pre-ictal-to-peak TcpCO2变化(16.4 [11.6,31.0]vs 2.2[0.45, 7.2]毫米汞柱,P = 0.023); and greater pre-ictal-to-nadir SPO2 change (24.0 [23.0,24.4] vs 4.1 [2.4,11.0] %, P=0.033). However, PGES was not associated with sleep state. In contrast, sleep seizures (N=35) were differentiated from wake seizures only by lower pre-ictal (19.9±2.5 vs 24.1±3.1 bpm, P<0.001), ictal (22.6±4.3 vs 28.0±2.7 bpm, P<0.001), and postictal RR (24.7±5.22 vs 8.5±4.4 bpm, P=0.020), and higher pre-ictal TcpCO2 (40.6[38.1, 42.6] vs 36.8[32.8, 39.5] mmHg, P=0.006).Conclusions: PGES (and not sleep) in perisylvian seizures is associated with a host of respiratory disturbances, providing further support of its role as a biomarker of SUDEP.Disclosure: Dr. Mora Munoz has nothing to disclose. Noah Andrews has nothing to disclose. Dr. Araujo has received personal compensation for serving as an employee of International Business Machines. Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Araujo has received research support from Inspire Medical System. Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving as a Consultant with One Heart Health. Dr. Aboussouan has received publishing royalties from a publication relating to health care. William Bingaman has nothing to disclose. Lu Wang has nothing to disclose. Dr. Grigg-Damberger has received personal compensation for serving as an employee of Oxford University Press. Dr. Grigg-Damberger has received personal compensation for serving as an employee of Up-to-date. Dr. Grigg-Damberger has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of Clinical Sleep Medicine. Dr. Grigg-Damberger has received publishing royalties from a publication relating to health care. Dr. Foldvary-Schaefer has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jazz. The institution of Dr. Foldvary-Schaefer has received research support from Jazz. The institution of Dr. Foldvary-Schaefer has received research support from Suven. The institution of Dr. Foldvary-Schaefer has received research support from Takeda. Dr. Foldvary-Schaefer has received publishing royalties from a publication relating to health care. Dr. Foldvary-Schaefer has received publishing royalties from a publication relating to health care.