TY - T1的梗塞地形和再灌注损伤后血管内血栓切除术对大血管闭塞中风(S20.002) JF -神经学乔-神经学做- 10.1212 / WNL。首页0000000000203704六世- 100 - 17补充2 SP - 4042 AU -罗伯特Regenhardt AU -安娜Bonkhoff AU -马库斯Schirmer AU -阿尔文Das AU -亚当Dmytriw AU -贾斯汀Vranic盟拉吉夫·古普塔AU -詹姆斯Rabinov AU -克里斯托弗Stapleton盟Thabele Leslie-Mazwi AU -阿曼Patel盟纳塔莉亚罗斯特Y1 - 2023/04/25 UR - //www.ez-admanager.com/content/100/17_Supplement_2/4042.abstract N2 -目的:量化梗塞组织有针对性的在MRI pre-e首页ndovascular血栓切除术(EVT),理解其重要性再灌注损伤和出血性转换(HT),并确定对临床和影像学特征。背景:随着适应症EVT持续扩张,理解再灌注损伤的病理生理学和HT变得越来越重要。Pre-EVT梗塞地形可能影响治疗决策(如支架),和职位EVT护理(如抗血栓形成的)。设计/方法:患者从前瞻性维护数据库。每个病人的扩散加权序列进行了手动梗塞描述和注册标准与皮质的空间叠加,皮层下白质地图册。HT被定义为eca PH1或PH2。0.10与术中变量;单变量分析是包含在多变量模型。结果:165名参与者(平均年龄69 (IQR 56 - 79), 56%的女性)被确定。静脉溶栓是管理的52%;70%达到TICI 2酮-再灌注。HT发生在8%。的分布pre-EVT梗塞(38 - 60%)白质48%,23%(6 - 47%)皮质,15%(4 - 28%)基底神经节。 Pre-EVT infarct volumes [median (IQR)] were 22 cc (12–43 cc) for total, 11 cc (6–19 cc) for white matter, 5 cc (1–19 cc) for cortex, and 3 cc (1–6 cc) for basal ganglia infarct. Paramagnetic sequences showed 3% had petechial hemorrhage and 40% had susceptibility vessel sign. Basal ganglia infarct volume was independently associated with HT (OR=1.342, 95%CI=1.002,1.797) in a model including white matter infarct volume, cortex infarct volume, smoking, and puncture-to-recanalization time. Basal ganglia infarct volume was linked to susceptibility vessel sign (Beta=0.233, p=0.006) and NIHSS (Beta=0.220, p=0.012), when controlling for total infarct volume.Conclusions: Greater basal ganglia infarct volume was associated with a higher risk of HT when accounting for infarct volumes in other regions. Susceptibility vessel sign was associated with basal ganglia infarct volume, which may be related to acute middle cerebral artery perforator occlusion.Disclosure: Dr. Regenhardt has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Rapid Medical. Dr. Regenhardt has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Johnson and Bell Trial Lawyers. The institution of Dr. Regenhardt has received research support from National Institutes of Health. The institution of Dr. Regenhardt has received research support from Society of Vascular and Interventional Neurology. The institution of Dr. Regenhardt has received research support from Heitman Foundation. Dr. Bonkhoff has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for NeuroImage Clinical (Elsevier). Dr. Schirmer has nothing to disclose. Dr. Das has nothing to disclose. Dr. Dmytriw has nothing to disclose. Dr. Vranic has nothing to disclose. Dr. Gupta has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for • ER -