TY - T1的疗效和生活质量的结果合并癫痫手术RNS位置(p5 - 1.002) JF -神经学乔-神经学做- 10.1212 / WNL。首页0000000000203703六世- 100 - 17补充2 SP - 4041 AU -杰锅盟Shazia Mirza盟-马克Agostini盟Rohit Das -萨沙Alick-Lindstrom盟盟菅直人叮AU -亚历山大·道尔盟Marisara Dieppa AU -瑞恩·海斯盟杰伊·哈维AU -布拉德利北方联盟党盟Irina Podkorytova AU -罗德里戈·塞盟Ghazala Perven Y1 - 2023/04/25 UR - //www.ez-admanager.com/content/100/17_Supplement_2/4041.abstract N2 -目的:回顾性评估患者临床结果在切除或激光间质热疗(LiTT)立即植入后RNS(≤90天)。首页背景:手术切除和LiTT标准治疗难治性癫痫,但这些选项可以通过雄辩的皮层和癫痫multifocality是有限的。先前的研究已经暗示RNS可用于结合resective手术(RNS + R)或LiTT (RNS + LiTT)作为一种新的治疗方法的结合。除了控制癫痫,生活质量和心理症状,包括抑郁和焦虑视为重要的结果评价癫痫手术后。设计/方法:34个病人,RNS + R或RNS + LiTT综述了在我们的中心和10个被排除在外。双重的决定程序是手术前。患者接受RNS + R都resective手术和RNS放置在同一个程序。患者接受RNS + LiTT已经几周差距RNS位置和LiTT由于神经外科物流。临床进行了跟进12日,18日,24日,36和48个月评价癫痫发作频率。病人健康questionnaire-9 (phq - 9)作为抑郁评估。癫痫患者的生活质量问卷(QOLIE-31)用作通用的生活质量评估得分。Results: Among the 24 patients that had RNS+R or RNS+LiTT, 22 patients (91.6%) showed improved seizure frequency at the last follow up. Fourteen patients had PHQ-9 evaluation and the average score was 5.85±6.29 (mean±SD), among which nine were between 0–4 (minimal depression), one was between 5–9(mild depression), three were between 10–14(moderate depression), one was 15–19(moderately severe depression) and none was 20–27(severe depression). QOLIE-31 done in eight patients showed average score of 65.61 ± 18.09 (mean±SD) in last follow-up visit.Conclusions: Our study showed significant seizure control rate of RNS+R or RNS+LiTT therapy in refractory epilepsy patients. It also suggestive for promising psychiatric outcomes and quality of life scoring after surgery.Disclosure: Dr. Pan has nothing to disclose. Dr. Mirza has nothing to disclose. Dr. Agostini has nothing to disclose. Dr. Alick-Lindstrom has nothing to disclose. Dr. Das has received personal compensation for serving as an employee of Concentra. Dr. Das has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for janicek. The institution of an immediate family member of Dr. Das has received research support from NIH. The institution of Dr. Ding has received research support from National Institute of Aging. The institution of Dr. Ding has received research support from NINDS. Dr. Doyle has nothing to disclose. Dr. Dieppa has nothing to disclose. Dr. Hays has nothing to disclose. Dr. Harvey has received personal compensation for serving as an employee of RSC Diagnostics. The institution of Dr. Harvey has received research support from GW Pharmaceuticals. The institution of Dr. Harvey has received research support from Cerevel Pharmaceuticals. The institution of Dr. Harvey has received research support from UCB Pharmaceuticals. The institution of Bradley Lega has received research support from NIH. irina podkorytova has nothing to disclose. Dr. Zepeda Garcia has nothing to disclose. Dr. Perven has nothing to disclose. ER -