% 0期刊文章% Guenther Deuschl % Griet罗兰转发%一诺伯特·科瓦奇%一个公关舒尔曼弗雷德里克克莱门特% % T震颤减少使用DBS:一个真实的结果,前瞻性多中心特发性震颤注册(p7 - 11.004) % D R 10.1212 / WNL 2023%。0000000000201927 % J首页神经病学% P V 100% N 17补充2% 1432% X目的:评估结果具有多个独立的定向DBS系统电流控制(MICC)技术在特发性震颤患者植入(ET)的护理标准。背景:等是最常见的神经系统疾病之一,影响到大约0.9%的世界人口。医疗专注于运动症状,管理和治疗选择包括药物治疗、腹侧中间核(Vim)丘脑切开术,和/或丘脑脑深部电刺激(DBS)。目前,Vim DBS推荐作为治疗选择合适的科目与ET (Zesiewicz Wharen 2017年,2005)。设计/方法:在这个前瞻性,标签上,多中心,国际DBS注册,登记患者植入定向MICC-based DBS系统(Vercise,波士顿科学)。病人随访3年,整体生活质量改善及评估等症状。不良事件也被收集。结果:迄今为止,30例植入(= 64.8±15.1岁意味着(SD), 53.1%的男性)意味着疾病持续时间为19.3年。17.3分的变化探索总结指数在12个月内代表指出临床显著差异(> 4.47分变化)(品特2019)。此外,平均9小时地震减少在一个典型的一天是指出在基线(14.7小时和6.5小时在12个月)。 Moreover, based on the severity scale of FTMTRS, when comparing disability at 12-months (vs Baseline), no patient reported experiencing marked disability (vs. 9.4% at Baseline), 16.7% reported moderate disability (vs. 81.3% at Baseline) and 83.3% reported mild disability (vs 9.4% at Baseline).Conclusions: Preliminary results from this ongoing registry show clinically important outcomes in quality of life, as well as motor function, thereby reflecting improvement in overall disability among patients (i.e., a disability profile moving from moderate/severe to more mild/moderate disability). This registry represents the first comprehensive, large-scale collection of real-world outcomes with MICC-based DBS systems for ET.Disclosure: Dr. Deuschl has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Boston Scientific Cavion Functional Neuromodulation. The institution of Dr. Deuschl has received research support from Medtronic. Dr. Deuschl has received publishing royalties from a publication relating to health care. Dr. Loret has nothing to disclose. The institution of Norbert Kovacs has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. The institution of Norbert Kovacs has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbott. The institution of Norbert Kovacs has received personal compensation in the range of $500-$4,999 for serving as a Consultant for boston Scientific. Norbert Kovacs has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbvie. Norbert Kovacs has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for Hungarian Scientific Parkinson’s Disease Society. The institution of Norbert Kovacs has received research support from Abbott. The institution of Norbert Kovacs has received research support from Hungarian National Research Board. Dr. Clement has nothing to disclose. P.R. Schuurman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Boston Scientific. P.R. Schuurman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medtronic. %U