作者@article {Loesslein2967 ={莉娜Loesslein和马赛厄斯Linnerbauer Thanos Tsaktanis和弗朗西斯科Quintana Veit Rothhammer}, title ={鼻内交付TGFα{\ textendash}一个新颖的治疗方法在多发性硬化病变决议?体积(p7 - 3.001)} ={100} ={17补充2},elocation-id = {2967} = {2023}, doi = {10.1212 / WNL。出版商0000000000202924}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:我们这里评估的治疗潜力tissue-protective TGFα决议的首页中枢神经系统炎症。背景:急性损伤后等中枢神经系统(CNS)在多发性硬化症(MS)、小胶质细胞之间的相互作用、星形胶质细胞和免疫细胞浸润定义了中枢神经系统的炎症微环境可以引起炎症或导致其chronification的分辨率。然而,小胶质细胞之间的相互作用,星形胶质细胞和免疫细胞浸润和组织损伤的解析是各自贡献差的特点。在这种背景下,我们最近发现microglia-derived TGFα女士作为小说司机的复苏及其临床前动物模型实验性自身免疫性脑脊髓炎(运算单元)。在这里,我们描述其监管的疾病和调查其转化潜力在中枢神经系统的急性炎症。设计/方法:我们这里使用CRISPR {\ textendash} Cas9-based遗传扰动模型,高维流式细胞术、免疫组织化学和磁共振成像(MRI),以及调整调查细胞在体外实验目标,净效果和治疗潜在microglia-derived TGFα复苏的女士及其临床实验性自身免疫性脑脊髓炎动物模型(运算单元)。结果:在急性中枢神经系统炎症,小胶质细胞分泌TGFαtemporospatial的方式管理在一个高度。我们表明小胶质TGFα复苏需要实验性自身免疫性脑脊髓炎减少浸润T细胞和炎性骨髓细胞的数量,以及减少少突细胞损失,轴突损伤,脱髓鞘。在治疗方法中,鼻内交付TGFα减少星形胶质细胞的促炎概要和中枢神经系统免疫细胞浸润,同时促进神经元存活和病变分辨率,因此促进临床康复。结论:在一起,我们表明,TGFα作用于神经胶质和浸润细胞促进中枢神经系统炎症的决议。 TGFα signaling might represent a novel checkpoint of CNS recovery, which offers therapeutic potential to promote recovery in acute and chronic stages of MS.Disclosure: Mrs. Loesslein has nothing to disclose. Mr. Linnerbauer has nothing to disclose. Dr. Tsaktanis has nothing to disclose. Dr. Quintana has nothing to disclose. Prof. Rothhammer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Prof. Rothhammer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. The institution of Prof. Rothhammer has received research support from German Research Foundation. The institution of Prof. Rothhammer has received research support from European Research Council.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/100/17_Supplement_2/2967}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }