% 0期刊文章%一个亚历山大·安德列夫%米切尔威尔逊%贾谊王%丹尼尔Forsman声称通过% Nadia麦克米兰斯莱姆% % Sonu萨尼% Magdy一Vasileios-Arsenios Lioutas % T急性脑出血(我)和系统性酸中毒:联想功能结果和死亡率(p7 - 5.026) % D R 10.1212 / WNL 2023%。0000000000203559 % J首页神经病学% P V 100% N 17补充2% 3836% X目的:本研究我们旨在评估协会我呼吸和代谢性酸中毒的功能结果和死亡率。背景:系统性酸中毒是常见的危重病设置和脑出血患者(我)经常需要插管和入住ICU。之间的关系我还没有调查和系统性酸中毒。设计/方法:回顾性单中心的患者急性自发的我。我们检查了酸中毒入院时之间的关系,(1)医院死亡率和(2)90天改良Rankin规模(夫人)一分为二不利(> 3)vs有利(≤3)。代谢性酸中毒是定义的存在下列之一:血清碳酸氢< 22毫克当量/ L乳酸> 2更易/ L或pH值< 7.35。呼吸性酸中毒是由二氧化碳分压> 45毫米汞柱。我们进一步分层分析重症监护病房与普通病房住院和插管状态。结果:共有406名患者,平均年龄80.5(±1.5)年,174女性(43%)和232(57%)的男性。134例(33%)患者酸中毒的承认,42例(10%)有呼吸性酸中毒,剩下的92名(23%)代谢性酸中毒。没有统计上显著的代谢性酸中毒与医院死亡率之间的联系(p = 0.21, 95% CI[0.37 - -1.24])或90天有利的功能结果(p = 0.61, 95% CI[0.37 - -1.24])调整后血肿体积和扩张,格拉斯哥昏迷评分,室间出血。 There was no association between respiratory acidosis with either hospital mortality (p=1.00) or functional outcome (p=1.00) before the adjustment for confounders. There was no effect modification after stratifying by ICU and intubation status.Conclusions: In this retrospective cohort study, we found that systemic acidosis was present in one third of patients with spontaneous ICH. Unlike other critical neurological conditions such as traumatic brain injury, there was no significant association between metabolic and respiratory acidosis with mortality and 90-day functional outcome in ICH.Disclosure: Dr. Andreev has nothing to disclose. Dr. Wilson has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Forsman has stock in Eli Lilly and Co. Dr. Forsman has stock in Moderna Inc. Dr. McMillan has nothing to disclose. Dr. Sahni has nothing to disclose. Dr. Selim has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MedRhythms Inc.. Dr. Lioutas has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Qmetis. Dr. Lioutas has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Heart Association. %U