RT期刊文章SR电子T1上颈绳卷及其与大脑关系指标(p10 - 3.012)摩根富林明神经学神经学乔女士FD Lippincott Williams &威尔金斯SP 4387 10.1212 / WNL。首页0000000000203950签证官100 17补充2 A1努尔Neyal A1胡继晔A1儿子克里斯托弗·施瓦兹A1伊丽莎白·阿特金森A1冬青莫里森A1约翰港口A1 Kejal Kantarci A1 Orhun Kantarci A1 Burcu Zeydan年2023 UL //www.ez-admanager.com/content/100/17_Supplement_2/4387.abstract AB目的:评估之间的首页联系上颈绳(UCC) MS.Background大脑体积和常见的指标:基于他们的可用性高于线核磁共振成像,UCC萎缩从大脑核磁共振成像评估作为成像常用的生物标志物相比,女士的测量整个颈绳,UCC萎缩可能没有那么敏感,但似乎女士与残疾相关指标。UCC也可能与其他成像指标MS.Design /方法:连续89 MS患者(63 f / 26米,72复发/ 17进步)是从一个前瞻性的中心。对大脑结构卷,自动LesionQuant (Cortechs实验室)使用。为降低脑干和UCC卷,一种新颖的自动化方法。传播的面具降低脑干和UCC地区从图谱模板空间每个脑磁共振t1,先进的非线性登记使用标准化的工具。卷被计算成图像的体素卷多勤劳的体素在面具的总和。自动卷从每个解剖水平(aMedulla、aCervicomedullaryJunction-aCMJ aC1, aC2)和总卷从髓质从CMJ C2 (aMedulla + UCC)和C2 (aUCC)被确定。结果:130年大脑核磁共振成像进行了分析。在核磁共振为46.0±12.3岁。个人aCMJ aC1, aC2卷和总卷(aMedulla + UCC和aUCC)与整个大脑和丘脑卷(p < 0.05)。 The strongest correlations were between aMedulla and whole brain (unadjusted r=0.67p<0.001; adjusted for age&sex r=0.59 p<0.001) and thalamus volumes (unadjusted r=0.53 p<0.001; adjusted for age&sex r=0.46 p<0.001).Conclusions: Besides the whole brain and thalamus volumes, brain imaging is also used to evaluate UCC atrophy in MS. These common imaging metrics are often considered as independent variables; however, they also seem to interact with each other. Therefore, in MS trials, a composite metric, especially accounting for thalamus and UCC volumes, could serve as a complementary imaging outcome.Disclosure: Dr. Neyal has nothing to disclose. Dr. Son has nothing to disclose. Christopher Schwarz has received personal compensation for serving as an employee of Mayo Clinic. The institution of Christopher Schwarz has received research support from NIH. Elizabeth Atkinson has nothing to disclose. Ms. Morrison has nothing to disclose. The institution of John D. Port has received research support from NIH. The institution of Dr. Kantarci has received research support from Eli Lilly. The institution of Dr. Kantarci has received research support from NIH. The institution of Dr. Kantarci has received research support from ADDF. Dr. Kantarci has nothing to disclose. The institution of Dr. Zeydan has received research support from National Institutes of Health.