TY -的T1 -随机,踢出PD waitlist-controlled试验:帕金森疾病特性空手道收益率高依从性和生活质量改善(p1 - 11.005) JF -神经学乔-神经学做- 10.1212 / WNL。首页0000000000202767六世- 100 - 17补充2 SP - 2743 AU - Jori弗AU - Katheryn吴盟-布兰娜Sennott AU -琼奥基夫非盟-钱德勒吉尔盟Sharlet安德森盟Nicollette珀塞尔AU - Bichun欧阳盟约书亚Chodosh Y1 - 2023/04/25 UR - //www.ez-admanager.com/content/100/17_Supplement_2/2743.abstract N2 -目的:测试的有效性和可持续性每周空手道课程设计为个人与轻度至中度首页帕金森病(PD)的生活质量和个人目标达到情况在6个月和维护的空手道练习12个月相比,个人随机候补名单。背景:空手道是一个组的武术将有氧、力量,抵抗,和正念训练,每个单独为PD患者带来好处。每周两次在我们的飞行员,PD-specific空手道类(PD)踢,我们演示了高保持率(79%)、依从性(87%),和18%提高生活质量超过十周,p = 0.01)。严格地测试这些发现,我们设计了一个六个月,随机、waitlist-controlled审判。设计/方法:我们与Hoehn招募和1:1随机个体,Yahr(衔接)阶段1 - 3 PD到六个月的每周两次,60分钟,免费,PD-specific空手道课程或等待控制。我们收集的基线人口、生活质量和个人参与的目标。我们评估依从性(%上课),生活质量,目标达到情况在6个月。最后,我们评估持续空手道练习活动小组12个月。结果:我们随机52个人(平均年龄:65.7岁,61.5%为男性,意味着PD持续时间:7.8年,88.5% HY 2)。平均出席率为92.5%,活跃的参与者经历了临床显著改善的生活质量(PDQ-8类内变化:24.2和15.0,p = 0.002),而对照组候补名单没有变化(p = 0.12)。在活跃的参与者中,84%实现他们的个人目标和63%自愿继续空手道课程在12个月。Conclusions: In this randomized, controlled trial, six months of karate for PD improved quality of life and was met with remarkable adherence and sustained 12-month participation. Future investigations into this promising exercise modality are indicated.Disclosure: The institution of Dr. Fleisher has received research support from Parkinson’s Foundation. The institution of Dr. Fleisher has received research support from NIH/NINDS. The institution of Dr. Fleisher has received research support from NIH/NINDS. The institution of Dr. Fleisher has received research support from NIH/NIA/Emory Roybal Center for Dementia Caregiving Mastery. Dr. Fleisher has received publishing royalties from a publication relating to health care. Dr. Fleisher has received personal compensation in the range of $0-$499 for serving as a Speaker with Parkinson’s Foundation. Dr. Fleisher has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Lewy Body Dementia Association. Dr. Fleisher has received personal compensation in the range of $0-$499 for serving as a Speaker with Davis Phinney Foundation. Dr. Fleisher has a non-compensated relationship as a Editorial Board Member with AAN Brain & Life Magazine that is relevant to AAN interests or activities. Miss Woo has nothing to disclose. An immediate family member of Dr. Sennott has received personal compensation for serving as an employee of Abbott Laboratories. Joan O’Keefe has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Avexis, Inc. Dr. Gill has nothing to disclose. Dr. Anderson has nothing to disclose. Nicollette Purcell has nothing to disclose. Bichum Ouyang has nothing to disclose. The institution of Dr. Chodosh has received research support from NIH-NIA. The institution of Dr. Chodosh has received research support from NIH-NIMHD. The institution of Dr. Chodosh has received research support from NIH-NINR. The institution of Dr. Chodosh has received research support from SCAN Health Plan. The institution of Dr. Chodosh has received research support from New York State Department of Health. ER -