@article {Barba10.1212 / WNL。0000000000207371,作者={洛伦佐胡须和萨米尔Abu-Rumeileh Steffen Halbgebauer和乔凡尼Bellomo费德里科•保利Paoletti洛伦佐Gaetani和帕特里克Oeckl Petra Steinacker费德里科•马萨和露西拉Parnetti和马库斯·奥托},title = {CSF突触生物标志物在路易身体疾病的(N)的子组},elocation-id = {10.1212 / WNL。={2023}0000000000207371},年,doi = {10.1212 / WNL。出版商0000000000207371}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标。首页路易的身体疾病患者(精神的小黑裙)经常显示共病的{\ textquoteright}年代老年痴呆症病理(广告)。脑脊液(CSF)生物标记允许检测体内AD-related病理特征包括在(N)分类系统。这里,我们旨在调查CSF突触和neuro-axonal损伤的生物标记是否与广告co-pathology面前的小黑裙,可以有助于区分的小黑裙在(N) profiles.Methods患者不同。我们回顾性测定CSF水平的广告核心生物标志物(Aβ42/40比率,p-tau t-tau)和突触(β-synuclein、α-synuclein SNAP-25, neurogranin)和neuro-axonal蛋白质(NfL)在28认知没有参与者non-degenerative神经疾病和诊断的161名参与者的小黑裙或广告(在轻度认知障碍、AD-MCI和痴呆阶段,AD-dem)。我们在临床脑脊液生物标志物的水平相比,在(N)的subgroups.Results。CSFβ-synuclein,α-synuclein、SNAP-25 neurogranin和NfL水平没有差异的小黑裙(n = 101 = 67.2 {\ textpm} 7.8岁,27.7 \ %的女性)和控制(= 64.8 {\ textpm} 8.6岁,39.3 \ %的女性)和增加广告(AD-MCI n = 30, AD-dem n = 30日= 72.3 {\ textpm} 6.0岁,63.3 \ %雌性)相比,两组(p \所有比较p < 0.001)。在小黑裙),我们发现增加突触和neuro-axonal变性患者的生物标记A + T +(小黑裙/ A + T +)与T -概要(小黑裙/ T -) (p \ < 0.01),β-synuclein显示,两组之间的区别的最高精度(AUC = 0.938, 95 \ % CI = 0.884 - 0.991)。 CSF β-synuclein (p = 0.0021), α-synuclein (p = 0.0099) and SNAP-25 concentrations (p = 0.013) were also higher in LBD/A+T+ than in LBD/A+T- cases, which had synaptic biomarkers levels within the normal range. CSF α-synuclein was significantly decreased only in LBD patients with T- profiles compared to controls (p = 0.0448). Moreover, LBD/A+T+ and AD cases did not differ in any biomarker level.Discussion. LBD/A+T+ and AD cases showed significantly increased CSF levels of synaptic and neuro-axonal biomarkers compared to LBD/A-T- and control subjects. LBD patients with AD co-pathology might, thus, experience similar degrees of synaptic dysfunction than pure AD cases.Classification of evidence. This study provides Class II evidence that CSF levels of β-synuclein, α-synuclein, SNAP-25, neurogranin and NfL are higher in patients with AD than in patients with LBD.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/early/2023/05/13/WNL.0000000000207371}, eprint = {//www.ez-admanager.com/content/early/2023/05/13/WNL.0000000000207371.full.pdf}, journal = {Neurology} }