TY -的T1 -编者注:净水吸收之间的联系和功能结果脑损伤患者的低方面:我上次的结果研究摩根富林明——神经学乔-神经病学SP - 191 LP - 191 - 10.1212 / WNL。首页0000000000207627六世- 101 - 4盟Aravind Ganesh AU -史蒂文Galetta Y1 - 2023/07/25 UR - //www.ez-admanager.com/c首页ontent/101/4/191.1.abstract N2 - Broocks博士等人研究了净水吸收(NWU)之间的关系,定量CT成像标记早期病变的水吸收,和功能结果在254患者的多中心观察研究大型船前循环中风。患者广泛早期缺血性变化反映在阿尔伯塔低中风项目早期CT评分(≤5方面反映出更多地区的参与)。他们发现高早期NWU独立与贫穷相关功能的结果,包括与机械血栓切除术、血管再通后认为NWU可能因此成为徒劳的血栓切除术患者低方面的指标。作为回应,Pensato博士等人指出,这项研究可能是使用的限制(ROI)的计算NWU在一个区域内的缺血性病变。鉴于可怜的高功能结果在最近血栓切除术在低方面的积极试验中风,他们建议结合方面与次区域NWU计算在每一个方面可以帮助患者更好的选择广泛的缺血性改变谁可以受益于血栓切除术。应对这些评论,作者认为小的好处在大型梗塞患者血栓切除术后可能进一步提高成像分层使用NWU结合方面。这交易突显出潜在的附加值定量成像标记,从常规行程可诱导的成像,在改善患者选择血栓切除术患者ASPECTS.Dr低。Broocks等人研究了净水吸收(NWU)之间的关系,定量CT成像标记早期病变的水吸收,和功能结果在254患者的多中心观察研究大型船前循环中风。患者广泛早期缺血性变化反映在阿尔伯塔低中风项目早期CT评分(≤5方面反映出更多地区的参与)。 They found that higher early NWU was independently associated with poorer functional outcome, including after recanalization with mechanical thrombectomy, and suggested that NWU might therefore serve as an indicator of futile thrombectomy in patients with low ASPECTS. In response, Dr. Pensato et al. note that the study may have been limited by the use of a region-of-interest (ROI)–based calculation of NWU in a single area within the ischemic lesion. Given the high rates of poor functional outcome seen in recent positive trials of thrombectomy in low ASPECTS stroke, they suggest that combining ASPECTS with NWU calculations in each ASPECTS subregion may help better select patients with extensive ischemic changes who can benefit from thrombectomy. Responding to these comments, the authors agree that the smaller margin of benefit after thrombectomy in patients with large infarcts may be improved by further imaging stratification using NWU in combination with ASPECTS. This exchange highlights the potential added value of quantitative imaging markers, derivable from routine stroke imaging, in improving patient selection for thrombectomy in patients with low ASPECTS. ER -