@article {VargasP6.217作者= {Alejandro巴尔加斯和詹妮弗天Ashkan Zarrieneh和Dilip Pandey Sepideh Amin-Hanjani和费尔南多Testai}, title ={神经认知功能的改善性烟雾外科搭桥患者(P6.217)},体积={88}={16}补充数量,elocation-id = {P6.217} ={2017},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:建立角色外科旁路性烟雾患者的神经认知功能。首页背景:性烟雾病人认知功能受损,常见临床表现在66 \ %的病例。低灌注的作用似乎是。直接比较的预处理和在性烟雾post-bypass手术患者没有明确研究文献中建立。我们假设搭桥手术可能会停止下降甚至改善性烟雾病人的神经认知状态。设计/方法:在这项研究中,我们回顾性收集数据性烟雾患者神经认知测试在两个不同的时间点,并分析了如果一个统计预处理和post-recanalization过程之间存在差异。并不是每一个病人接受所有相同的神经认知测试。预处理和需要术后测试分数平均和比较采用配对t检验。结果:十14测试显示稳定或提高成绩后测试。只有四个14测试显示分数下降的趋势。结论:我们的结果显示稳定的神经认知功能。 Interestingly, though not statistically significant, our data do show a trend to improvement in neurocognitive test scoring. The fact that improved perfusion resulted in improved testing supports a hypoperfusion mechanisms for neurocognitive deficits. It may be implied that further decline would occur as stenosis and hypoperfusion increase as disease progresses. Baek et al reported in 2014 a preliminary study of five patients where memory domains showed an improvement, but all data was not statistically significant. Our study is the largest cohort of Moyamoya patients where pre-operative and post-operative neurocognitive testing was performed in order to assess the benefit of bypass surgery. Neurocognitive impairment may be an indication for earlier intervention with reperfusion procedures that can improve cognitive function, but prospective data is necessary.Disclosure: Dr. Vargas has nothing to disclose. Dr. Orning has nothing to disclose. Dr. Zarrieneh has nothing to disclose. Dr. Pandey has nothing to disclose. Dr. Amin-Hanjani has received research support from GE Healthcare,VasoSol Inc., and NIH. Dr. Testai has nothing to disclose.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/88/16_Supplement/P6.217}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }