@article {AdamczukP5.097作者= {Katarzyna Adamczuk和迈克尔Stepanovic和莎拉Makaretz和迈克尔Brickhouse新闻官克里斯蒂娜•卡索和梅根Quimby和里克Vandenberghe布拉德福德迪克森},title ={比较代谢减退和皮质萎缩的原发性进行性失语(P5.097)},体积={88}={16}补充数量,elocation-id = {P5.097} ={2017},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:比较代谢减退和萎缩在原发性进行性失语语言区域内(PPA)的病人。首页背景:比较的领土受到萎缩和代谢减退将阐明PPA的一系列病理生理变化。我们假设微妙的代谢减退可检测在PPA影响语言地区还不显示皮质萎缩。设计/方法:30右手PPA患者接受正从结构磁共振成像在12个月内。正被量化标准摄入值比率与脑桥参考区域。摄影图像局部体积修正。分析了核磁共振扫描根据FreeSurfer管道。代谢减退和萎缩Z-maps计算基于一组30年龄和性别匹配的控制从哈佛衰老的大脑研究。FDG和皮质厚度Z分数之间的差异在核心语言地区相比,非语言感兴趣的区域,和控制区域,通过重复测量方差分析。区域定义基于静息状态功能磁共振成像分析的一个独立样本。结果:代谢减退和皮质萎缩本地化主要左半球区域参与了PPA的语言障碍。在额叶和顶叶语言地区,区域与皮质萎缩小,包含在区域显示代谢减退。 Temporal areas were affected by hypometabolism and atrophy to comparable extent. Quantitatively, FDG Z scores were lower than cortical thickness Z scores in frontal and parietal language areas on the left and right. In temporal areas cortical thickness Z scores were lower than FDG Z scores, only on the left. Control region and other regions did not show significant differences. Regional differences between FDG and cortical thickness Z scores were different among 3 PPA subtypes.Conclusions: Our data suggest that hypometabolism is present without co-occurring atrophy in parts of the PPA affected language regions, which likely indicate future disease spread.Disclosure: Dr. Adamczuk has nothing to disclose. Dr. Stepanovic has nothing to disclose. Dr. Makaretz has nothing to disclose. Dr. Brickhouse has nothing to disclose. Dr. Caso has nothing to disclose. Dr. Quimby has received personal compensation for activities with Massachusetts General Hospital as an employee. Dr. Vandenberghe has received research support from GE Healthcare, Wyeth, Eli Lilly, Medivation, and Pfizer. Dr. Dickerson has received personal compensation for activities with Merck as a consultant. Dr. Dickerson has received personal compensation in an editorial capacity for Neuroimage: clinical.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/88/16_Supplement/P5.097}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }