@article {ChanP6.188金宝慱官网下载111作者={阿曼达·陈,这个日本徐怀钰和杰罗姆Devaux艾纳怀尔德史密斯},title ={小纤维神经病:分类和搜索自身免疫对周围神经组件(P6.111)},体积={88}={16}补充数量,elocation-id = {P6.111} ={2017},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目标:我们的目标是确定病因特发性案件背后的小纤维神经病(SFN),并提供了一个系统化的方法SFN的病人。首页背景:疼痛是一种常见的症状在患者小纤维神经病,涉及Aδ- c fibers的选择性。条款{\ textquoteleft}痛苦的神经病变{\ textquoteright}或{\ textquoteleft}自主神经病变{\ textquoteright}是SFN的同义的。原因包括遗传、代谢、感染性、毒性、药物和免疫介导性条件,但往往潜在的病因仍不清楚在15 {\ textendash} 30 \ %的病例。我们背后的病因分类并确定SFN的特发性原因情况下在我们的机构。设计/方法:患者作为特发性SFN异常皮肤活检和正常电生理检测和分类根据临床资料。{\ textquoteright}患者血清免疫球蛋白检测在背根神经节和腰椎脊髓部分。反应性测试已知的节点或paranodal蛋白(抗体neurofascin 155年和186年,contactin1, CASPR1, NrCAM, gliomedin, Kv7和钾通道。2/7.3)。结果:临床病程在3例急性,达到最低点后28天内症状。他们的急性期血清强烈彩色小神经纤维棕榈的真皮,和硝唑PGP 9.5,神经标记。 By contrast, immunoreactivity was nearly absent in the convalescent phase. Fifteen patients showed a chronic onset and sera tested negative for a variety of nerve antigens. We propose that SFN can be broadly classified into {\textquotedblleft}acute{\textquotedblright} or {\textquotedblleft}chronic{\textquotedblright}, and suggest the acronym {\textquotedblleft}acute painful autoimmune neuropathy{\textquotedblright} (aPAiN), and {\textquotedblleft}chronic painful autoimmune neuropathy{\textquotedblright} (cPAiN).Conclusions: Our aPAiN patients suggest that an acute immune response may be the cause of symptoms. Our negative findings of cPAiN patients suggest a different etiology. Further studies are required to identify the immunological etiologies behind the two differing syndromes of aPAiN and cPAiN. This may help to improve treatment strategies.Disclosure: Dr. Chan has nothing to disclose. Dr. Yuki has received personal compensation in an editorial capacity for Expert Review of Neurotherapeutics and Journal of the Neurological Sciences. Dr. Devaux has nothing to disclose. Dr. Wilder Smith has nothing to disclose.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/88/16_Supplement/P6.111}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }