PT -期刊文章盟-阿曼达·陈盟这个日本雪盟——杰罗姆Devaux盟艾纳怀尔德史密斯TI -小纤维神经病:分类和搜索自身免疫对周围神经组件(P6.111) DP - 2017年4月18日TA -神经病学PG - P6.111 VI - 88 IP - 16补充4099 - //www.ez-admanager.com/content/88/16_Supplement/P6.111.short 4100 - http://188金宝慱官网下载www.ez-admanager.com/content/88/首页16_Supplement/P6.111.full所以Neurology2017 4月18日;88 AB -目标:我们的目标是确定病因特发性案件背后的小纤维神经病(SFN),并提供了一个系统化的方法SFN的病人。背景:疼痛是一种常见的症状在患者小纤维神经病,涉及Aδ- c fibers的选择性。术语“痛苦的神经病变”或“自主神经病变”是SFN的同义的。原因包括遗传、代谢、感染性、毒性、药物和免疫介导性条件,但往往潜在的病因在15 - 30%的情况下仍不清楚。我们背后的病因分类并确定SFN的特发性原因情况下在我们的机构。设计/方法:患者作为特发性SFN异常皮肤活检和正常电生理检测和分类根据临床资料。病人的血清免疫球蛋白检测在背根神经节和腰椎脊髓部分。反应性测试已知的节点或paranodal蛋白(抗体neurofascin 155年和186年,contactin1, CASPR1, NrCAM, gliomedin, Kv7和钾通道。2/7.3)。结果:临床病程在3例急性,达到最低点后28天内症状。 Their acute phase sera strongly stained small nerve fibers in the dermis of palm, and co-localized with PGP 9.5, a nerve marker. By contrast, immunoreactivity was nearly absent in the convalescent phase. Fifteen patients showed a chronic onset and sera tested negative for a variety of nerve antigens. We propose that SFN can be broadly classified into “acute” or “chronic”, and suggest the acronym “acute painful autoimmune neuropathy” (aPAiN), and “chronic painful autoimmune neuropathy” (cPAiN).Conclusions: Our aPAiN patients suggest that an acute immune response may be the cause of symptoms. Our negative findings of cPAiN patients suggest a different etiology. Further studies are required to identify the immunological etiologies behind the two differing syndromes of aPAiN and cPAiN. This may help to improve treatment strategies.Disclosure: Dr. Chan has nothing to disclose. Dr. Yuki has received personal compensation in an editorial capacity for Expert Review of Neurotherapeutics and Journal of the Neurological Sciences. Dr. Devaux has nothing to disclose. Dr. Wilder Smith has nothing to disclose.

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