RT期刊文章SR电子T1理解使用无创通气治疗肌萎缩性脊髓侧索硬化症在美国和欧洲:国际医生的调查结果(P5.071)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP P5.071 VO 88是16补充A1特里Heiman-Patterson A1优点Cudkowicz A1 Mamede De卡瓦略A1安吉拉其全称A1欧Hardiman A1 Carlayne杰克逊A1诺亚Lechtzin首页 A1 Hiroshi Mitsumoto A1 Vincenzo Silani A1史黛西Rudnicki A1莎拉Kulke A1 Jinsy安德鲁斯A1伦纳德Van den Berg年2017 UL //www.ez-admanager.com/content/88/16_Supplement/P5.071.abstract AB目的:了解首选临床实践和识别障碍关于启动/使用无创通气(NIV)在肌萎缩性脊髓侧索硬化症(ALS)。背景:症状进展ALS患者需要呼吸支持,和合改善生活质量和延长生存。然而,和合起始时间和临床参数的差异和保险规定时可能会影响需求。设计/方法:25-item问卷调查是通过调查猴子®ALS专家鉴定通过加入尼尔(美国)和ENCALS(欧盟)。描述性统计/对比美国/欧盟反应进行了综述。结果:74/119(62.2%)的受访者治疗≥76 ALS患者/年(我们:40/71 (56.3%);欧盟:34/48 [70.8%])。当考虑和合、美国和欧盟专家价值直立FVC最正直人不同关于MIP(我们:2;欧盟:5)和隔夜脉搏血氧仪(美国:6;欧盟:2)。无呼吸道症状的病人,大多数美国专家发起和合FVC / SVC < 50%预测直立VC(我们:41/60 (68.3%); EU: 10/39 [25.6%];p<.001); no single criterion was identified by most EU physicians. When recommending NIV, US specialists more often refer patients to home agencies and trials/instructions occur at home (US: 39/57 [68.4%]; EU: 5/39 [12.8%];p<.001); EU specialists more often admit patients to hospital (US: 0/57 [0%]; EU: 16/39 [41.0%];p<.001). US specialists prefer to use certain ventilators non-invasively (US: 25/57 [43.9%]; EU: 5/39 [12.8%];p=.002); most EU specialists allow pulmonologists to decide (US: 11/57 [19.3%]; EU: 25/39 [64.1%];p<.001). Without influences of insurance/financial constraints, a greater number of US than EU specialists (US: 44/57 [77.2%]; EU: 6/39 [15.4%];p<.001) would alter when they prescribe NIV.Conclusions: NIV prescribing differs between the US and EU and may be influenced by insurance/financial constraints. Considering optimal NIV use influences patient survival and that differences in initiation and use also exist across the US, these differences can confound results in ALS treatment studies. This information may inform research, guideline revisions, and clinical use of NIV in ALS.Disclosure: Dr. Heiman-Patterson has nothing to disclose. Dr. Cudkowicz has received personal compensation for activities with Cytokinetics, Lilly, Astra Zenica, Biohaven, Genentech. Jama Neurology. Dr. De Carvalho has nothing to disclose. Dr. Genge has received personal compensation for activities with Novartis as a consultant and employee. Dr. Hardiman has received royalty payments from the Royal College of Surgeons in Ireland. Dr. Jackson has nothing to disclose. Dr. Lechtzin has nothing to disclose. Dr. Mitsumoto has received personal compensation for activities with Cytokinetics, Shinogi Pharma, and Biogen. Dr. Silani has nothing to disclose. Dr. Rudnicki has nothing to disclose. Dr. Kulke has nothing to disclose. Dr. Andrews has received personal compensation for activities with Cytokinetics, Inc. as an employee. Dr. van den Berg has received personal compensation for activities with Baxter as a consultant, and from Biogen and Cytokinetics as an advisory board member.