PT -期刊文章盟亚伦袭击非盟- Gamaleldin奥斯曼盟Nishi Rampal AU -悉达多Biswal AU -本杰明Legros盟-劳伦斯·赫希AU -布兰登·m·威斯多佛盟尼古拉斯TI -加斯帕德多态生存分析癫痫预测连续脑电图(P2.229) DP - 2017年4月18日TA -神经病学PG - P2.229 VI - 88 IP - 16补充4099 - //www.ez-admanager.com/content/88/16_Supplement/P2.229.short 4100 - //www.ez-admanager.com/content/88/16_Su首页pplement/P2.229.full所以Neurology2017 4月18日;88 AB -目的:确定风险因素和时间依赖性连续脑电图的癫痫发作的风险。背景:之前连续脑电图分析危险因素预测回顾和不受控制的审查/主题退出的影响。改正这一缺点,我们使用多态生存分析连续665年连续脑电图记录。设计/方法:回顾性分析665年预期获得数据库连续连续脑电图会话(在24小时内)与临床相关因素和脑电图数据包括事件的时间。Elastic-net逻辑回归是用来确定预测风险因素的时间独立变量,随后使用Cox比例风险模型。与时间有关的变量被用来创建一个多态生存模型与三个州(输入、风险状态和扣押)。定义的风险状态的出现癫痫样的模式:单侧性的周期放电(lpd),两国独立定期排放(BIPDs),简短的有节奏的排放(惟妙惟肖),单侧性的有节奏的三角洲活动(LRDA),和/或零星的痫性放电(SED)。引导是用于生成95%的置信区间。结果:电记录的癫痫发生在23%的cEEG监测会议。 Time independent variables of greatest predictive value were coma (31% had seizures on EEG; O.R 1.8 p<0.01) and any history of seizures: either remotely or acutely (34% had electrographic seizures; OR 3.0 p<0.001). Four multistate survival models were generated dependent on the time independent variables (coma, history of seizure). The overall 72-hour risk of seizures was between 0.09–0.36 if the subject did not develop epileptiform EEG patterns, and 0.18–0.64 if the subject developed epileptiform patterns. After 6hrs the risk of seizures declined from 0.04–0.16 at 1hour of recording to 0.02–0.09 if no epileptiform EEG patterns developed, and to 0.08–0.34 if they did.Conclusions: The risk of seizures on continuous EEG is dependent on history of seizure and presence of coma. The risk of developing seizures during a continuous EEG decays quickly if no epileptiform EEG patterns emerge.Disclosure: Dr. Struck has nothing to disclose. Dr. Osman has nothing to disclose. Dr. Rampal has nothing to disclose. Dr. Biswal has nothing to disclose. Dr. Legros has nothing to disclose. Dr. Hirsch has received personal compensation for activities with Ceribell, Marinus, Monteris, Neuropace, Sun Pharma, Sunovion, and Upsher-Smith as an speaker. Dr. Hirsch has received research support from Acorda, Eisai, Lundbeck, Sunovion and Upsher-Smith. Dr. Westover has nothing to disclose. Dr. Gaspard has nothing to disclose.

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