PT -期刊文章盟Naomi Nevler盟沙龙灰非盟-查尔斯·杰斯特盟大卫欧文AU -马克Liberman盟穆雷格罗斯曼TI -语调作为行为变异额颞叶退化疾病标记(P4.186) DP - 2017年4月18日TA -神经病学PG - P4.186 VI - 88 IP - 16补充4099 - //www.ez-admanager.com/content/88/16_Supplement/P4.186.short 4100 - //www.ez-admanager.com/content/首页88/16_Supplement/P4.186.full所以Neurology2017 4月18日;88 AB -目的:量化行为变异的语调额颞叶退化(bvFTD)使用半自动的声学分析和评价临床和神经解剖协会。背景:韵律是至关重要的沟通、传达情感和语言信息。表达韵律一直具有挑战性的定量评估。我们开发了一个半自动的演讲分析协议和假设异常语调non-aphasic bvFTD与相关社会神经网络。设计/方法:我们分析了数字化半结构化的语音样本从32 bvFTD病人(21岁男性,平均年龄63±8.5,意味着疾病持续时间4±3.1年)和17匹配控制。我们自动提取基频(f0、声音的物理性质与音高感知关联)和音高范围计算对数刻度(半音程、圣),控制个人和性别差异。我们f0范围相关神经精神病学的库存(NPI)的病人的一个子集。我们相关f0灰质(GM)萎缩在12个月内使用3 t磁共振T1获得记录的演讲。结果:音高范围明显缩小在bvFTD(平均4.3±1.8)相对于控件(5.8±2.1;p = 0.03)。没有发现相关的f0与任何NPI子量表评分范围。 Regression related f0 range in bvFTD to GM atrophy in bilateral anterior, inferior and dorsomedial frontal as well as left anterior insular regions (p<.05, uncorrected).Conclusions: Reduced f0 range reflects impaired intonation in bvFTD. This is validated by the correlation of expressive prosody with an established frontal neuroanatomic network associated with social cognition. This measure of intonation is not directly related to the NPI. These findings support the feasibility of automated speech analysis in FTD and other disorders.Disclosure: Dr. Nevler has nothing to disclose. Dr. Ash has nothing to disclose. Dr. Jester has nothing to disclose. Dr. Irwin has nothing to disclose. Dr. Liberman has received personal compensation for activities with Imperium and the Henry Law firm as a consultant. Dr. Grossman has received personal compensation for activities with Avid. Dr. Grossman has received personal compensation in an editorial capacity for Neurology. Dr. Grossman has received research support from BMS.