PT -期刊文章盟Lars Høj Markvardsen AU -克里斯蒂安Overgaard AU -卡伦Heje盟Søren Sindrup AU - Ingelise克里斯琴森盟-约翰vis AU -亨宁安徒生TI -交替阻力和耐力训练可以提高肌肉力量和有氧能力患者的慢性炎性脱髓鞘多神经病(P4.142) DP - 2017年4月18日TA -神经病学PG - P4.142 VI - 88 IP - 16补充4099 - //www.ez-admanager.com/content/88/16_Supplement/P4.142.short 4100 - //www.ez-admanager.com/content/88/16_Supplement/P4.142.full所以Neurology2017 4月18日;首页88 AB -目的:探讨有氧和抵抗运动的影响患者的慢性炎性脱髓鞘多神经病(CIDP)。背景:有氧运动和阻力运动导致更高的有氧能力和各种神经肌肉疾病患者的肌肉力量。然而,稀疏描述是否患有慢性炎性脱髓鞘多神经病(CIDP)从锻炼中受益。设计/方法:在这个控制研究中,十八CIDP患者皮下免疫球蛋白被分配到12周的有氧运动之后,12周的抵抗运动,反之亦然。锻炼之前,所有病人的试车期12周没有任何预定的运动。有氧运动每周至少三次进行一个测力计的自行车在一个强度最大心率的70%。抵抗运动每周进行三次单边训练的膝盖和肘部弯曲/扩展与常规负荷的增加。主要结果有氧能力(氧气摄入量)和最大等速肌力的膝盖和肘部弯曲/扩展。生活质量(QoL)和疲劳是次要参数。结果:13例完成会话和四个完成有氧(n = 2)或阻力训练时期(n = 2)。 During the run-in period, neither VO2-max nor muscle strength changed (26±6 vs. 26±6 ml*min−1*kg−1 (p=0.80) and 245±83 vs. 246±85 Nm (p=0.17)). Following aerobic exercise, VO2-max increased by 11%, (27±7 to 30±7 ml*min−1*kg−1 (p=0.02)). Resistance exercise resulted in a 14% increase in combined muscle strength of upper and lower extremities (243±77 to 276±91 Nm (p=0.0004)). QoL and fatigue were unchanged.Conclusions: Aerobic and resistance exercise training are safe and improve fitness and strength in CIDP patients treated with immunoglobulin.Study Supported by:Sponsored by Octapharma PharmaceuticalsDisclosure: Dr. Markvardsen has received personal compensation for activities with Octapharma Pharmaceuticals as a speaker. Dr. Markvardsen has received research support from Octapharma Pharmaceuticals. Dr. Overgaard has nothing to disclose. Dr. Heje has nothing to disclose. Dr. Sindrup has nothing to disclose. Dr. Christiansen has nothing to disclose. Dr. Vissing has received personal compensation for activities with Alexion Pharmaceuticals and Ultragenyx as an advisory board member. Dr. Andersen has nothing to disclose.

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