TY -的T1神经活动的动态响应平均动脉压和Neurocritical干预以蛛网膜下腔出血后颅内脑电图(P2.280) JF -神经学乔-神经学六世- 88 - 16补充SP - P2.280盟盟Apeksha Shenoy -卢卡斯Fleuren AU -哈斯。Biswal盟-艾米丽博伊尔非盟-萨哈尔征服者AU -阿曼Patel盟- m .威斯多佛盟-埃里克·罗森塔尔Y1首页 - 2017/04/18 UR - //www.ez-admanager.com/content/88/16_Supplement/P2.280.abstract N2 -目的:我们研究生理参数之间的关系不断地记录在一个Neurocritical护理和定量脑电图颅内高档蛛网膜下腔出血(SAH)后记录。我们评估neurocritical干预的影响(镇静和血管加压的政府)通过检查确定的轶事颅内脑电图(iEEG)临床反应被认为是有意义的。背景:SAH病人可能经历从癫痫脑代谢的供需不匹配,血管痉挛,皮质传播去极化,脑积水、脑水肿。先前的研究都集中在non-neuronal脑自动调整的措施。设计/方法:SAH病人Hunt-Hess 3 - 5年级接受1)临床多峰性neuromonitoring利用斯宾塞深度电极,脑组织氧脑血氧定量法,脑血流量,通过quad-lumen螺栓及软式ICP,和/或2)神经外科的一个硬膜下电极条知情同意后使用时间同步监测(cns - 210,支持研究)。我们平均生理数据和工件减少光谱情节在10世纪,封存在增量的生理参数。我们删除离群值在生理范围内(0.5% ile)。我们将病人分成DCI(延迟脑缺血)与non-DCI集团基于临床裁定。我们显示的数据作为一个脑电图频率谱图在生理参数,血压、入住ICU。我们计算定量脑电图(qEEG)α和三角洲的特性,比如权力乐队做个比较。结果:16高档SAH患者可用post-SAH iEEG数据超过21个月。地图——依赖光谱特性是指出在特定的病人。 5 patients visually demonstrated a positive correlation of power in the alpha and delta bands with increasing blood pressure; 4 showed negative correlation. In two DCI patients, this relationship changed over time (pre-DCI vs. post-DCI).Conclusions: Neuronal function in the setting of SAH may be modifiable across the range of blood pressure changes. The EEG biomarker of DCI may also be modifiable in a critical period allowing interventions before irreversible injury occurs.Study Supported by: A. David Heitman Foundation for Neurovascular ResearchDisclosure: Dr. Shenoy has nothing to disclose. Dr. Fleuren has nothing to disclose. Dr. Biswal has nothing to disclose. Dr. Boyle has nothing to disclose. Dr. Zafar has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Westover has nothing to disclose. Dr. Rosenthal has nothing to disclose. ER -