% 0期刊文章% Varun Chauhan % Kalyan Yarraguntla %的Navid Seraji-Bozorgzad %一个保分%莫妮卡Dhakar % Maysaa岜沙% Aashit Shah % T大杏仁核卷患者“癫痫突然意外死亡”(P2.237) % D J神经病学2017% % P P2.237 X % V % 88% N 16补充目的:评估的形态学变化皮质厚度、丘脑、纹状体和脑干卷之间突然意外死亡患者癫痫(癫痫)和其他癫痫病。首页背景:尽管预测模型提出了癫痫,这些临床预测因素缺乏敏感性。之前的研究已经涉及杏仁核和边缘系统在癫痫发病机理,通过他们在自主的角色可能不稳定。我们出发去探索潜在的癫痫预测标记使用的形态学分析。设计/方法:年龄匹配癫痫(n = 8),局灶性癫痫与二级泛化(FEWSG, n = 6),主要全身性癫痫(铂族元素,n = 8)和健康的控制(HC, n = 8)患者纳入回顾性研究。高分辨率结构组成的核磁共振T1加权图像被用于FreeSurfer提取皮质厚度和深度灰质卷。多变量分析,其次是Mann-Whitney测试(SPSS第23节)来评估集团在每个的形态学差异变量。卷在立方厘米,毫米皮质厚度。结果:患者FEWSG和铂族元素小皮质厚度和深度灰质结构与健康对照组相比。除了杏仁核、皮质厚度和纹状体在癫痫患者也小与健康对照组相比,但大相比其他癫痫病。杏仁核体积明显高于癫痫组(3.42±0.5,p < 0.007),相比其他癫痫(铂族元素:2.88±0.5; FEWSG: 2.5±0.5), approaching that of healthy controls (3.21±0.3, p=0.32) respectively.Conclusions: A relatively larger amygdala volume, along with lower cortical thickness and striatal volume may predict the risk of SUDEP in patients with epilepsy. Furthermore, our data supports the role of amygdala, possibly through the retroflex fasciculus or other functional pathway projecting onto the pre-Botzinger complex in ventro-lateral medulla, in pathogenesis of SUDEP. Further studies to validate our findings is warranted.Disclosure: Dr. Chauhan has nothing to disclose. Dr. Yarraguntla has nothing to disclose. Dr. Seraji-Bozorgzad has nothing to disclose. Dr. Bao has nothing to disclose. Dr. Dhakar has nothing to disclose. Dr. Basha has nothing to disclose. Dr. Shah has received personal compensation from UCB Pharma and Lundbeck as a speaker. %U

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