RT期刊文章SR电子T1舒马曲坦规范化偏头痛attack-related增加大脑5 -羟色胺合成摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 431 OP 439 10.1212/01. wnl.000029909首页5.65331.6f VO 70是6 A1 y酒井法子A1 c·多布森A1 m . Diksic A1 m·奥布河A1 e·哈默尔年2008 UL //www.ez-admanager.com/content/70/6/431.abstract AB背景:改变5 -羟色胺(5 -)神经传递与偏头痛的病理生理学。目的:测试这个假说在偏头痛患者体内使用宠物和α- c [11] methyl-l-tryptophan代孕的标志大脑5 -合成率在不同阶段的偏头痛攻击和急性antimigraine治疗后舒马曲坦,并与正常对照组进行比较。方法:6例进行扫描1)自发偏头痛的发病后6小时内攻击,2)2小时后皮下舒马曲坦,3)当偏头痛发作至少3天免费。头痛是额定每个扫描之前,之前和每15分钟后舒马曲坦。结果:大脑5 -合成在攻击最高,最低后舒马曲坦,中间当患者偏头痛自由。所有国家在统计学上不同于其他几乎所有的大脑区域。5 -合成率在偏头痛发作的病人没有年龄的差异,sex-matched控制,而他们舒马曲坦在大多数地区后显著降低。发作,全球大脑5 -合成率略,虽然不明显,偏头痛患者的低(−14%)比控制,按比例与特定的皮质表现出更严重的削减(−28%至31%)。结论:这些结果指向皮质低血清素激活的语气在偏头痛患者发作。进一步,他们证明普遍增加大脑5 -羟色胺(5 -)合成率在偏头痛患者的攻击,这药物发挥负反馈调节大脑5 -合成与调制同时痛苦的途径。 5-HT=serotonin; α-[11C]MTrp; Amy=amygdala; ANOVA=analysis of variance; B=bilateral pain; Cau=caudate; Cin=cingulate; Co=cortex; dBS=dorsal brainstem (including the periaqueductal gray matter and dorsal raphe nucleus); DSM-III-R=Diagnostic and Statistical Manual of Mental Disorders, third revised edition; Fro=frontal cortex; FWHM=full-width at half-maximum; Hipp=hippocampus; HSD=honest significant difference; IHS=International Headache Society; L=left hemicrania; MWA=migraine with aura; MWOA=migraine without aura; NS=not significant; Occ=occipital cortex; Par=inferior parietal cortex; Put=putamen; R=right hemicrania; R > L=mainly right hemicrania; RMANOVA=repeated-measures analysis of variance; ROI=region of interest; TAC=time–activity curve; Tha=thalamus; TSc1/d=time after Scan 1, in days; TS/m=time after sumatriptan injection, in minutes, at beginning of Scan 2; TO/h=time after migraine onset, in hours and minutes, at beginning of Scan 1.

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