PT -期刊文章AU - Elisa Canu AU - Federica Agosta盟Vladana·马尔科维奇AU -阿尔贝托Inuggi盟Milica Jecmenica盟弗朗西斯卡Imperiale AU -亚历山德拉Tomic盟弗拉基米尔·s . Kostic AU -马西莫菲利皮主持TI缰的角色和杏仁核在帕金森症患者鱼池(S1.004) DP - 2017年4月18日TA -神经病学PG - S1.004 VI - 88 IP - 16补充4099 - //www.ez-admanager.com/content/88/16_Supplement/S1.004.short 4100 - //www.ez-admanager.com/c首页ontent/88/16_Supplement/S1.004.full所以Neurology2017 4月18日;88 AB -目的:扩大我们的知识在帕金森氏症患者的奖励网络故障鱼池(PD-punding)评估功能连通性的系带和杏仁核与PD患者没有任何冲动控制障碍(PD no-ICD)。背景:鱼池ICD的差调查部分光谱影响大约7%的PD患者和潜在的生理和心理健康造成严重威胁。设计/方法:52 (22 PD-punding) PD患者和30名健康对照进行了t1加权静息状态功能磁共振成像。功能连通性的缰双边和杏仁核是由seed-based方法。皮质厚度的措施,系带和杏仁核卷。结果:功能连通性分析表明,控制和PD no-ICD相比,PD-punding患者增强双边缰和杏仁核之间的连接和双边丘脑、纹状体;和减少两国之间的连接系带和左额前皮质,和右杏仁核和海马。之间的正相关关系被发现时间白天鱼池和连通性留给缰的海马旁回、海马和丘脑,右缰的右颞中回。系带和杏仁核卷没有组间差异。PD-punding病人显示皮质萎缩的右额下回控制和PD no-ICD相比,和进一步的额叶,顶叶和颞变薄而控制。结论:PD-punding与地区之间的断开调制奖励电路(即。、系带和杏仁核)和结构上额叶皮质受损,这些领域之间的联接和其他皮层下结构。 These alterations may reflect the repetitive behavior despite the lack of reward in PD-punding. This study offers opportunities for the detection of PD patients at risk for punding and future directions for therapeutic intervention.Study Supported by: Ministry of Education and Science Republic of Serbia (Grant #175090).Disclosure: Dr. Canu has nothing to disclose. Ms. Agosta has received personal compensation for activities with EXCEMED - Excellence in Medical Education as a speaker. Dr. Markovic has nothing to disclose. Dr. Inuggi has nothing to disclose. Dr. Jecmenica has nothing to disclose. Dr. Imperiale has nothing to disclose. Dr. Tomic has nothing to disclose. Dr. Kostic has received personal compensation for activities with Novartis, Boehringer Ingelheim Pharmaceuticals, Merck & Co., Inc., Lundbeck Research USA, Inc., GlaxoSmithKline, Hoffman-La Roche, Alkaloid, and Dr. Filippi has received personal compensation for activities with Biogen Idec, Excemed, Novartis, and Teva as a consultant and/or speaker.