% 0期刊文章% w . j . Jagust % s·m·兰道% l . m . Shaw % j .问:Trojanowski % R . A . Koeppe % e . m . Reiman % n·l·福斯特%一个R·c·彼得森% m·w·维纳% j . c .价格% c·A·马修斯%的阿尔茨海默病的神经影像学% T生物标记物之间的关系在衰老和痴呆% D R 10.1212 / WNL 2009%。0 b013e3181bc010c % 首页J神经病学% P 1193 - 1199 V % 73% 15% N X背景:PET成像使用[18 f]氟脱氧葡萄糖(FDG)和c[11]匹兹堡化合物B(加以提出了作为阿尔茨海默病(AD)的生物标志物,CSF措施的42个氨基酸β-amyloid蛋白质(Aβ1-42)和总和磷酸化τ(t-tau和p-tau)。生物标志物和疾病严重程度之间的关系是不完全理解。方法:10个主题广告,11个对照组,和34个科目的轻度认知障碍的阿尔茨海默病的神经影像学进行临床评估;CSF Aβ1-42测量,t-tau, p-tau;PIB-PET和正子扫描。数据分析使用连续的回归和二分结果与学科分类为“积极的”或“消极的”广告基于达标患者建立广告从其他组和控制。结果:两个分类显示PIB-PET之间实质性的协议和CSF Aβ1-42措施(91%的协议,κ= 0.74),适度的协议PIB-PET和p-tau(76%的协议,κ= 0.50)和最小协议其他比较(κ< 0.3)。细微精神状态检查得分显著正相关,但不与PIB-PET或脑脊液Aβ1-42。回归模型调整的诊断显示,PIB-PET与Aβ1-42显著相关,t-tau,和p-tau181p,而摄影是只有Aβ1-42相关。 Conclusions: PET and CSF biomarkers of Aβ agree with one another but are not related to cognitive impairment. [18F]fluorodeoxyglucose-PET is modestly related to other biomarkers but is better related to cognition. Different biomarkers for Alzheimer disease provide different information from one another that is likely to be complementary. A=42 amino acid β-amyloid protein; AD=Alzheimer disease; ADNI=Alzheimer’s Disease Neuroimaging Initiative; CDR=Clinical Dementia Rating; CI=confidence interval; FDG=[18F]fluorodeoxyglucose; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; MR=magnetic resonance; PIB=[11C]Pittsburgh compound B; p-tau=phosphorylated tau; ROC=receiver operating characteristic; ROI=region of interest; SUVR=standardized uptake value ratio; t-tau=total tau; WMS-R=Wechsler Memory Scale–Revised. %U //www.ez-admanager.com/content/neurology/73/15/1193.full.pdf