RT期刊文章SR电子T1协会血浆淀粉样β痴呆的风险与摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 847 OP 853 10.1212 / WN首页L。0 b013e3181b78448 VO 73 11 A1 j - c。兰伯特A1 s Schraen-Maschke A1 F。理查德A1 n Fievet A1 o . Rouaud A1 c Berr A1 j - f。Dartigues A1 c Tzourio A1。Alperovitch A1 l . Buee A1 p Amouyel年2009 UL http://n.neu首页rology.org/content/73/11/847.abstract AB目的:一些证据表明,减少脑脊液浓度的淀粉样蛋白β42 (Aβ42)是一种潜在生物标志物事件阿尔茨海默病。相比之下,研究等离子体Aβ1-40和Aβ1-42肽水平产生了矛盾的结果。在这里,我们探讨了事件之间的联系痴呆和等离子Aβ1-40前瞻性和Aβ1-42肽浓度,以人群为基础的征(3 c)的研究。我们也评估了等离子体浓度的截断Aβ之间的联系(Aβn-40和Aβn-42)和老年痴呆症的风险。方法:在随后的4年随访期间,257人提出事件从8414名参与者痴呆,和1185个人没有subcohort痴呆了控制人群。等离子体水平的Aβ1-40,Aβ1-42、Aβn-40 Aβn-42测量使用xMAP-based试验技术。 The association between plasma Aβ peptide levels and the risk of dementia was assessed using Cox proportional hazard models. Results: Of the various Aβ variables analyzed, the Aβ1–42/Aβ1–40 and Aβn-42/Aβn-40 ratios presented the strongest association with the risk of dementia: people with a high Aβ1–42/Aβ1–40 or Aβn-42/Aβn-40 ratio had a lower risk of developing dementia. These associations were restricted to individuals diagnosed at 2 years of follow-up and the Aβn-42/Aβn-40 ratio was mainly associated with the risk of mixed/vascular dementia. Conclusion: Plasma Aβ peptide concentrations and Aβ1–42/Aβ1–40 and Aβn-42/Aβn-40 ratios may be useful markers to indicate individuals susceptible to short-term risk of dementia. Aβ=amyloid β; AD=Alzheimer disease; BMI=body mass index; CI=confidence interval; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders, 4th edition; HDL=high-density lipoprotein; HR=hazard ratio; INSERM=Institut National de la Santé et de la Recherche Médicale; MCI=mild cognitive impairment; 3C=Three-City.