PT -期刊文章盟Matteo Grammatico AU -安娜Repice盟乔凡娜卡卢奇AU -路易莎Vuolo盟克劳迪娅美琪AU -亚历山德罗Barilaro盟Enrico Fainardi AU -卢卡Massacesi TI -核磁共振表征“中央静脉标志”的脑白质病变的多发性硬化症患者但可能“诊断”更好的解释(P4.400) DP - 2017年4月18日TA -神经病学PG - P4.400 VI - 88 IP - 16补充4099 - //www.ez-admanager.com/content/88/16_Supplement/P4.400.short 4100 - //www.ez-admanager.com/content/88/16_Supplement/P4.400.full所以Neurology2017 4月18日;首页88 AB -目的:分析“中央静脉标志”(CVS)在多发性硬化(MS)患者被误诊为高危患者可能“更好的解释”。背景:误诊可能发生在约5 - 10%的情况下,女士主要是因为未指明的MRI诊断标准。然而MS的病理特点的perivenular位置inflammatory-demyelinating脑白质病变(宝马)现在可以被常规核磁共振方法可视化,使体内歧视女士病变的病变由于小动脉的慢性微血管并发症或偏头痛(Mistry et al . 2015;所罗门et al . 2015年)。除了CVS女士也可以歧视辆宝马车从缺血性病变病灶由于inflammatory-autoimmune微血管并发症,通常以MS-like临床课程(Vuolo l . et al . 2015年)。Analyisis CVS的明确的女士和女士因此报告误诊的危险。设计/方法:入选标准:明确的女士或小姐与预定义的临床、血清学和MRI标准可能的“更好的解释”的诊断,但不满足其他疾病的诊断标准(女士)。每个病人收到一个大脑核磁共振(1.5 T)包括体积T2 * epi序列和天赋后钆注入。白质病变被认为是perivenular如果intralesional hypointense信号完全包围hyperintense信号至少2垂直的飞机。结果:42例(定27日和15 MS)到目前为止完成了分析。组间年龄、疾病和残疾时间相当。中值频率/病人的病变与CVS是89%(范围= 68 - 100%)女士定组和17.5%(范围= 9 - 78%)可能MS组。 Categorizing the patients AS CVS positive or negative according to a CVS frequency ≥ 68%, all the Definite MS resulted positive, whereas 10/15 Possible MS resulted negative. (66%)Conclusions: Analysis of the CVS frequency can improve specificity of the current MRI criteria for the diagnosis of MS.Disclosure: Dr. Grammatico has nothing to disclose. Dr. Repice has received personal compensation for activities with Biogen Idec , Genzyme, Novartis, and Merck Serono as a speaker and advisory board member. Dr. Carlucci has nothing to disclose. Dr. Vuolo has nothing to disclose. Dr. Mechi has nothing to disclose. Dr. Barilaro has nothing to disclose. Dr. Fainardi has nothing to disclose. Dr. Massacesi has nothing to disclose.