@article {Masur1572作者={大卫Masur和什洛莫Shinnar Avital克纳安和露丝c . Shinnar佩吉·克拉克和时代王埃里卡·维斯和黛博拉·g·Hirtz特雷西·a .底盘儿童失神癫痫的研究小组},title ={预处理认知缺陷和治疗对注意力的影响在儿童失神癫痫},体积={81}={18},页面= {1572 - 1580}= {2013},doi = {10.1212 / WNL。出版商0 b013e3182a9f3ca} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:确定神经认知赤字与新诊断治疗儿童失神癫痫(CAE),开发一个模型来描首页述物品的阶乘结构测量学术成就和3神经心理结构,并确定短期微分乙琥胺神经心理的影响的关注,丙戊酸,和拉莫三嗪。与新诊断方法:受试者CAE进入一个双盲、随机对照临床试验有神经心理学测试包括评估的一般智力功能,注意力、记忆、执行功能、和成就。注意力重新评估在第16周{\ textendash} 20访问。结果:在研究条目,36 \ %的群体表现出注意力尽管否则完整的神经认知功能。结构方程建模的基本神经心理学数据显示直接顺序效应之间的注意,记忆、执行功能和学术成就。在第16周{\ textendash} 20访问,注意力坚持即使发作是获得自由。更多的受试者接受丙戊酸(49 \ %)比受试者接受注意力乙琥胺(32 \ %)、拉莫三嗪(24 \ %)(p = 0.0006)。父母的评估没有可靠地检测治疗之前或之后注意力(p < 0.0001)。结论:儿童CAE预处理注意力率高赤字持续尽管没收自由。利率是不成比例的高丙戊酸治疗而乙琥胺或拉莫三嗪。 Parents do not recognize these attentional deficits. These deficits present a threat to academic achievement. Vigilant cognitive and behavioral assessment of these children is warranted.Classification of evidence: This study provides Class I evidence that valproic acid is associated with more significant attentional dysfunction than ethosuximide or lamotrigine in children with newly diagnosed CAE.ADHD=attention deficit hyperactivity disorder; AED=antiepileptic drug; ANOVA=analysis of variance; CAE=childhood absence epilepsy; CBCL=Child Behavior Checklist; CI=Confidence Index; CPT=Continuous Performance Test; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders, 4th edition; K-CPT=Kiddie Continuous Performance Test; RCT=randomized clinical trial; SE=standard error; WRAT-3=Wide Range Achievement Test 3}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/81/18/1572}, eprint = {//www.ez-admanager.com/content/81/18/1572.full.pdf}, journal = {Neurology} }