RT期刊文章SR电子T1预处理认知缺陷和治疗对注意力的影响在儿童失神癫痫摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 1572 OP 1580 10.1212 / WNL。首页0 b013e3182a9f3ca VO 81是18 A1大卫Masur A1什洛莫Shinnar A1 Avital克纳安A1露丝c Shinnar A1佩吉·克拉克A1时代王A1埃里卡·格劳瑟维斯A1黛博拉·g·Hirtz A1特雷西a A1儿童失神癫痫的研究小组2013年UL //www.ez-admanager.com/content/81/18/1572.abstract AB目的:确定神经认知赤字与新诊断治疗儿童失神癫痫(CAE),开发一个模型来描述物品的阶乘结构测量学术成就和3神经心理结构,并首页确定短期微分乙琥胺神经心理的影响的关注,丙戊酸,拉莫三嗪。与新诊断方法:受试者CAE进入一个双盲、随机对照临床试验有神经心理学测试包括评估的一般智力功能,注意力、记忆、执行功能、和成就。注意在本周重新评估16 - 20访问。结果:在研究入口,36%的群体表现出注意力尽管否则完整的神经认知功能。结构方程建模的基本神经心理学数据显示直接顺序效应之间的注意,记忆、执行功能和学术成就。在本周访问16 - 20日,注意力坚持即使发作是获得自由。更多的受试者接受丙戊酸(49%)比受试者接受注意力乙琥胺(32%)或拉莫三嗪(24%)(p = 0.0006)。父母的评估没有可靠地检测之前或之后注意力治疗(p < 0.0001)。结论:儿童CAE预处理注意力率高赤字持续尽管没收自由。利率是不成比例的高丙戊酸治疗而乙琥胺或拉莫三嗪。 Parents do not recognize these attentional deficits. These deficits present a threat to academic achievement. Vigilant cognitive and behavioral assessment of these children is warranted.Classification of evidence: This study provides Class I evidence that valproic acid is associated with more significant attentional dysfunction than ethosuximide or lamotrigine in children with newly diagnosed CAE.ADHD=attention deficit hyperactivity disorder; AED=antiepileptic drug; ANOVA=analysis of variance; CAE=childhood absence epilepsy; CBCL=Child Behavior Checklist; CI=Confidence Index; CPT=Continuous Performance Test; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders, 4th edition; K-CPT=Kiddie Continuous Performance Test; RCT=randomized clinical trial; SE=standard error; WRAT-3=Wide Range Achievement Test 3