TY -的T1 - Post切除Electro-corticography预测癫痫发作的结果——一个多元逻辑分析(P6.339) JF -神经学乔-神经学六世- 82 - 10补充SP - P6.339 AU -索尼娅Krish盟Omotola希望非盟首页——Giridhar Kalamangalam AU -杰里米·斯莱特盟Nitin Tandon Y1 - 2014/04/08 UR - //www.ez-admanager.com/content/82/10_Supplement/P6.339.abstract N2 -目的:评估post-resection ECoG峰值对癫痫的位置,存在一个明显的损伤,和持续时间的癫痫和癫痫手术后确定预测评估。背景:Electrocorticogophy (ECoG)阐述建构主义的程度和特点病灶或雄辩的皮层。切除后的效用ECoG录音在预测结果或指导癫痫手术切除尚不清楚。方法:从195例患者的前瞻性编译数据库癫痫手术由一个癫痫外科医生德克萨斯大学的综合项目,6个月对患者术后数据编译18岁及以上。独立变量包括post-resection ECoG(0 =没有排放,1 =微妙的或罕见的排放2 =重要的排放),癫痫发作,癫痫的持续时间,切除类型(1 =中央的时间,2 =颞皮层和3 = extra-temporal)和病理类型(1 =海绵状瘤/肿瘤,2 = (MTS) /内侧颞叶硬化灶皮质发育不良(FCD), 3 =胶质增生/异位神经元/脑软化)。有序逻辑回归分析用于预测癫痫预后的ILAE(国际抗癫痫联盟)规模。结果:75例患者纳入分析,有52人(69.3%)内侧颞叶手术,7例(9.3%)颞皮层只有手术和16(21.3%)额外的颞皮层病例。病理发现15例海绵状瘤/肿瘤,40例MTS / FCD和20例神经胶质过多症等其他非特异性病理/脑软化。Logistic regression model incorporating these variables revealed that nonspecific pathologies categorized in group 3 (gliosis/ heterotopias/ encephalomalacias) > MTS/FCD > defined lesions categorized in group 1 (such as tumor/cavernoma) predicted a higher i.e. worse ILAE outcome score (OR=1.65(1.29; 5.46). Post resection spikes significant > rare >none predicted higher ILAE outcome score (OR=1.91(1.08; 3.38). CONCLUSIONS: Pathology predicts outcome after epilepsy surgery. Nonspecific pathologies such as gliosis and post-resection spike discharges predicted worse outcome after epilepsy surgery. The location of surgery did not predict outcomes after epilepsy surgery.Disclosure: Dr. Krish has nothing to disclose. Dr. Hope has nothing to disclose. Dr. Kalamangalam has nothing to disclose. Dr. Slater has received personal compensation for activities with Cyberonics, Novartis, Ortho, and UCB Pharma. Dr. Tandon has nothing to disclose.Thursday, May 1 2014, 7:30 am-11:00 am ER -