Machado-Joseph TY - T1的脊髓损伤的神经学疾病(P6.043) JF -乔-神经学六世- 82 - 10补充SP - P6.04首页3盟卡米拉Fahl AU -卢卡斯Branco AU -菲利普Bergo盟Iscia Lopes-Cendes AU - Marcondes语言,Jr . Y1 - 2014/04/08 UR - //www.ez-admanager.com/content/82/10_Supplement/P6.043.abstract N2 -目的:评价脊髓损伤Machado-Joseph疾病(SCA3)通过定量分析MRI扫描。背景:SCA3是世界范围内最常见的脊髓小脑的共济失调和显著的表型异质性的特征。SCA3 mri研究集中在小脑和连接,但对脊髓损伤疾病及其临床意义。设计/方法:一组48 SCA3的分子确认患者(26人)和48岁的准确性健康对照组进行了高分辨率核磁共振在3 t Achieva-Intera飞利浦扫描仪。我们使用t1 3 d图像覆盖整个大脑和颈部脊髓估计颈脊髓面积和偏心(ECC)三个C2和C3水平基于半自动图像分割协议。采集参数:TE = 3.2毫秒,TR = 7.1毫秒,翻转角度= 8 o,体素的大小= 1.0 x 1.0 x 1.0毫米,FOV = 240 x240。此外,该量表评估和评级的共济失调(SARA)是用来量化疾病严重程度。集团与学生t检验进行比较。我们使用皮尔逊系数研究MRI及临床数据之间的相关性。假定值& lt; 0.05被认为是重要的。 RESULTS: Mean age of SCA3 patients was 47.7±12.9 years. In this group, mean duration of disease was 9.0±4.4 years. The two groups - SCA3 and controls - were significantly different regarding spinal cord areas (49.5±7.3 vs 67.2±6.3 mm², p<0.001) and ECC values (0.79±0.06 vs 0.75±0.05, p=0.005). In addition, spinal cord areas presented a significant correlation with disease duration (r=-0.315, p=0.029) and SARA scores (r=-0.423, p=0.003) in the patient group. CONCLUSIONS: SCA3 is characterized by cervical cord atrophy and flattening. In addition, spinal cord areas did correlate with disease severity. This suggests that quantitative analyses of spinal cord MRI might be a useful biomarker in SCA3. Study Supported by: Conselho Nacional de Pesquisas - Brazil (CNPq)Disclosure: Dr. Fahl has nothing to disclose. Dr. Branco has nothing to disclose. Dr. Bergo has nothing to disclose. Dr. Lopes-Cendes has nothing to disclose. Dr. Franca, Jr. has nothing to disclose.Thursday, May 1 2014, 7:30 am-11:00 am ER -