@article {LiuS43.006作者= {Anli刘和奥林Devinsky和安德鲁·布莱恩特和Ashlie杰斐逊和丹尼尔·弗里德曼和Mouhsin戴尔和威廉·巴尔和丹尼尔媒体和苏珊·赫尔曼和玛格丽特·O {\ textquoteright}康纳和史蒂文Schachter} Alvaro pascual - leone, title ={功效的经颅直流电刺激颞叶癫痫患者的工作记忆和情绪(S43.006)},体积={82}={10}补充数量,elocation-id = {S43.006} ={2014},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:我们的目标是评估系列会议是否经颅直流电刺激可以诱发改善工作记忆功能,抑郁症状,并控制颞叶癫痫患者的生活质量。首页背景:记忆功能障碍和抑郁常常与颞叶癫痫共病。经颅直流电刺激(tDCS)是一种安全、非侵入性的大脑神经调节方法。以前的试点研究使用tDCS演示了对工作记忆和抑郁情绪健康和神经受损的科目。设计/方法:这是一项随机,双盲,假对照试验研究和24个成人患者(年龄18 - 62)严格的颞叶癫痫。阳极是放在左背外侧前额叶皮层和阴极右眼眶上的地区。受试者随机活动tDCS手臂收到马5的2直流电的20分钟。我们执行一些措施的口头和视觉空间工作记忆,情绪(贝克抑郁量表(BDI),神经障碍抑郁症库存癫痫[NDDI-E]),生活质量(癫痫[QOLIE-31])的生活质量,和前后发作频率刺激,2和4周后。结果:受试者随机分配到治疗手臂是相似的教育背景,言语智商,发作频率,基线工作记忆和情绪得分与对照组相比。我们发现积极的而不是虚假的tDCS显著提高情绪得分来衡量BDI NDDI-E,但没有改善工作记忆的表现。 There was a trend toward benefit in quality of life (QOLIE-31). There was no increase in the frequency of seizures during or after active stimulation. CONCLUSIONS: Active but not sham tDCS significantly improved mood symptoms and did not increase seizure frequency in patients with well-controlled temporal lobe epilepsy. Study Supported by: Epilepsy Foundation, American Epilepsy Society, American Brain FoundationDisclosure: Dr. Liu has nothing to disclose. Dr. Devinsky has received personal compensation in an editorial capacity for Epilepsy \& Behavior. Dr. Bryant has nothing to disclose. Dr. Jefferson has nothing to disclose. Dr. Friedman has received personal compensation for activities with UCB Pharma and Schwartz Biosciences. Dr. Shafi has nothing to disclose. Dr. Barr has nothing to disclose. Dr. Press has nothing to disclose. Dr. Herman has received research support from Lundbeck Research USA, Inc., Vertex, Inc., UCB Pharma, Eisai, Inc. and Fidelity Biosciences Research Initiative. Dr. O{\textquoteright}Connor has nothing to disclose. Dr. Schachter has received personal compensation for activities with Johnson \& Johnson, Marinus Pharmaceuticals, Neurotherapeutics, and Sepracor. Dr. Schachter has received personal compensation for activities with Elsevier. Dr. Schachter has received contractual rights to payments from Cyberonics. Dr. Pascual-Leone has received personal compensation for activities with Nexstim, Neuronix, Starlab Neuroscience, Neuroelectrics, Neosync, and Novavision. Dr. Pascual-Leone has received personal compensation in an editorial capacity for the European Journal of Neurology. Dr. Pascual-Leone has received research support from Nexstim and Neuronix.Wednesday, April 30 2014, 4:00 pm-5:45 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/82/10_Supplement/S43.006}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }