PT -期刊文章盟蕾妮de Bruijn盟奥斯卡佛朗哥- Maarten利恩盟盟-阿尔伯特·霍夫曼AU -彼得Koudstaal AU -穆罕默德伊TI -心脏功能和痴呆的风险(P5.212) DP - 2014 Apr 08年TA -神经病学PG - P5.212 VI - 82 IP - 10补充4099 - //www.ez-admanager.com/content/82/10_Supplement/P5.212.short 首页4100 - //www.ez-admanager.com/content/82/10_Supplement/P5.212.full所以Neurology2014 Apr 08年;82 AB -目的:探讨心脏功能和痴呆的风险之间的联系社区老年人免费的临床心脏病。背景:临床心脏病,如冠心病、心力衰竭、房颤,一直与痴呆和认知障碍。然而,亚临床心脏功能障碍之间的关系和事件痴呆是未知的和调查的优点。设计/方法:本研究是未来的一部分,鹿特丹以人群为基础的研究。使用超声心动图,我们测量了结构、舒张期和收缩期心脏功能参数基线(2002 - 2005)的3396名参与者(60.5%为女性,平均年龄71.5岁)冠心病、心力衰竭、房颤和痴呆。后续对痴呆几乎是完整的(97.9%),直到2012年。模型调整年龄、性别,随后对心率、收缩压和舒张压,使用降血压药物,总胆固醇、脂蛋白胆固醇、糖尿病、吸烟、体重指数、MMSE-score, APOE-ε4载体的地位。我们分别重复分析调查审查后阿尔茨海默病和中风。结果:在19998人年的随访226人发展事件痴呆。 In fully adjusted models, we found strongest associations with dementia for mitral valve inflow peak E (hazard ratio (HR) per SD increase 0.86; 95%CI 0.77-0.97), E/A-ratio (HR 0.82; 95%CI 0.71-0.96), mitral valve inflow deceleration time (HR 1.17; 95%CI 1.04-1.33), and intraventricular septum thickness (HR 1.16; 95%CI 1.01-1.32). Worse diastolic function (impaired relaxation or restrictive pattern) and worse systolic function were borderline associated with an increased risk of dementia. Results were similar for Alzheimer disease and after censoring for stroke. CONCLUSIONS: Cardiac function is associated with the risk of dementia and Alzheimer disease, independently of cardiovascular risk factors and stroke. These results suggest that subclinical cardiac dysfunction is an independent risk factor for dementia. Hence, the utility of echocardiography for screening purposes for dementia should be further investigated.Disclosure: Dr. de Bruijn has nothing to disclose. Dr. Leening has nothing to disclose. Dr. Franco has received research support from ErasmusAGE. Dr. Hofman has received personal compensation in an editorial capacity for the European Journal of Epidemiology. Dr. Koudstaal has nothing to disclose. Dr. Ikram has nothing to disclose.Wednesday, April 30 2014, 3:00 pm-6:30 pm