% 0期刊文章%一个蒂埃里王桂萍%艾德里安出席% Puttini普%一个Andreas Steck Susanne Renaud % % T慢性炎性脱髓鞘多神经病(CIDP)皮肤活检基因表达分析(P4.121) % D J神经病学2014% % P P4.121 % V 82% N 10补充% X目的:确定哪些分子变化出现在CIDP患者的皮肤,一个微阵列基因表达分析。首页背景:CIDP是一种少见的自身免疫性神经病变,临床表现的异质性,病人被诊断出结合临床、实验室和电诊法的研究。直到现在还没有已知生物标志物诊断疾病或评估其预后。设计/方法:我们执行转录分析微阵列分析小腿穿孔皮肤活检从20 CIDP患者和17名健康对照组。不同规范基因可能发病机理中的作用CIDP被定量PCR分析进一步证实了。结果:190个不同调节基因被确定在CIDP患者中,152年上调和38衰减。大多数基因是参与免疫和炎症反应,神经系统发育,细胞粘附,应对受伤,血管生成和凋亡过程。26个基因与假定的角色由qPCR CIDP的发病机理也被证实。四个基因被抑制,由MHC II级家族成员的基因:HLA-DPA1, HLA-DPB1 HLA-DQB2。其它22个基因上调,包括基因编码趋化因子CXCL12 CCR2),或参与增殖和修复(PDGF1、VEGFR和KDR A2M, CAV2 NOSTRIN)。 CONCLUSIONS: These findings indicate that gene expression is modified in the skin biopsies of CIDP patients with prominent evidence of changes in inflammatory pathways, and show the interplay of key pro-inflammatory factors involved in innate autoimmunity together with the activation of oxidative stress mechanisms. On the other hand several repair and protective factors are also activated. It will be the subject of future research to determine the sequential profile of these changes and evaluate the products of the potential gene markers in the target tissues.Disclosure: Dr. Kuntzer has nothing to disclose. Dr. Panaite has nothing to disclose. Dr. Stefania has nothing to disclose. Dr. Renaud has nothing to disclose. Dr. Steck has nothing to disclose.Wednesday, April 30 2014, 7:30 am-11:00 am %U

map